Evidence map›Paper›PMID 28951527›Full record

ArticleGenetics2017

Ethanol Stimulates Locomotion via a G

James R Johnson, Mark R Edwards, Huw Davies, Daniel Newman, Whitney Holden, Rosalind E Jenkins, Robert D Burgoyne, Robert J Lucas, Jeff W Barclay

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. AlteredeNeuro · 2026
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  3. Joubert syndrome genemicroPublication biology · 2026
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  4. Advances in drug addiction research usingFrontiers in cell and developmental biology · 2026
    Review
  5. Review
  6. AlteredbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. microPublication biology · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

James R JohnsonThe Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.
Mark R EdwardsThe Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.
Huw DaviesThe Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.
Daniel NewmanThe Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.
Whitney HoldenThe Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.
Rosalind E JenkinsDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.
Robert D BurgoyneThe Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.
Robert J LucasFaculty of Biological and Medical Sciences, University of Manchester, M13 9PT, UK.
Jeff W BarclayThe Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK barclayj@liverpool.ac.uk.ORCID 0000-0003-4320-2094
University of Liverpool · GBUniversity of Manchester · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Biotechnology and Biological Sciences Research Council BB//K002252/1Medical Research Council G0801731NIH HHS P40 OD010440Wellcome TrustWellcome Trust 088779/Z/09/Z
6 · The paper itself

Abstract

Alcohol is a potent pharmacological agent when consumed acutely at sufficient quantities and repeated overuse can lead to addiction and deleterious effects on health. Alcohol is thought to modulate neuronal function through low-affinity interactions with proteins, in particular with membrane channels and receptors. Paradoxically, alcohol acts as both a stimulant and a sedative. The exact molecular mechanisms for the acute effects of ethanol on neurons, as either a stimulant or a sedative, however remain unclear. We investigated the role that the heat shock transcription factor HSF-1 played in determining a stimulatory phenotype of

Indexed as

LocomotionSignal TransductionAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCentral Nervous System AgentsChemoreceptor CellsCyclic AMPCyclic AMP-Dependent Protein KinasesEthanolGTP-Binding Protein alpha Subunits, GsPhosphoproteinsTranscription FactorsVesicular Transport ProteinsCaenorhabditis elegans ProteinsCentral Nervous System AgentsCyclic AMPCyclic AMP-Dependent Protein KinasesEthanolGTP-Binding Protein alpha Subunits, Gsheat shock factor-1, C elegansPhosphoproteinsTranscription FactorsUnc-18 protein, C elegansVesicular Transport ProteinsalcoholHSF1optogeneticsprotein kinase AUNC-18

Identifiers

PMID28951527
PMCPMC5676223
OpenAlexW2757668320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.