Evidence map›Paper›PMID 28951454›Full record

ArticleCancer research2017

Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma.

Smruthy Sivakumar, F Anthony San Lucas, Tina L McDowell, Wenhua Lang, Li Xu, Junya Fujimoto, Jianjun Zhang, P Andrew Futreal, Junya Fukuoka, Yasushi Yatabe and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 124 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Signaling pathways and targeted interventions for precancers.Signal transduction and targeted therapy · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. LncRNA TMEM99 Complexes with IGF2BP2 to Inhibit Autophagy in Lung Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. eLife · 2025
    Article
  11. Review
  12. The Current Roadmap of Lung Cancer Biology, Genomics and Racial Disparity.International journal of molecular sciences · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Smruthy SivakumarDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
F Anthony San LucasDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Tina L McDowellDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Wenhua LangDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Li XuDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Junya FujimotoDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jianjun ZhangDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
P Andrew FutrealDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Junya FukuokaGraduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yasushi YatabeDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.
Steven M DubinettDivision of Pulmonology and Critical Care Medicine, University of California Los Angeles, Los Angeles, California.
Avrum E SpiraSchool of Medicine, Boston University, Boston, Massachusetts.
Jerry FowlerDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ernest T HawkDivision of Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ignacio I WistubaDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Paul ScheetDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas. pscheet@alum.wustl.edu hk94@aub.edu.lb.
Humam KadaraDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas. pscheet@alum.wustl.edu hk94@aub.edu.lb.
The University of Texas MD Anderson Cancer Center · USAichi Cancer Center · JPBoston University · USUniversity of California, Los Angeles · USUniversity of Nagasaki · JP

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Statistical Methods for Population Genomics and "Next-gen" Sequencing DataR01HG005859 · NHGRI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SCHEET, PAUL A · 2011 to 2015
$1.9M
NCI NIH HHS P30 CA016672NHGRI NIH HHS R01 HG005859
6 · The paper itself

Abstract

There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AAH, LUAD, and normal tissues. Somatic

Indexed as

GenomicsAdenocarcinomaAgedDisease ProgressionFemaleGene Expression ProfilingHumansHyperplasiaLungLung NeoplasmsMaleMiddle AgedMutationPrecancerous ConditionsProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)BRAF protein, humanKRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)

Identifiers

PMID28951454
PMCPMC5774855
OpenAlexW2760267264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.