Evidence map›Paper›PMID 28951425›Full record

ArticleJournal of leukocyte biology2017

Differential T cell homing to colon vs. small intestine is imprinted by local CD11c

Amiran Dzutsev, Alison Hogg, Yongjun Sui, Shahram Solaymani-Mohammadi, Huifeng Yu, Blake Frey, Yichuan Wang, Jay A Berzofsky

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Intestinal CD8European journal of immunology · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. The Role of Integrin αCurrent HIV/AIDS reports · 2018
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amiran DzutsevVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Alison HoggVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Yongjun SuiVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA suiy@mail.nih.gov.
Shahram Solaymani-MohammadiVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Huifeng YuVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Blake FreyVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Yichuan WangVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Jay A BerzofskyVaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA berzofsj@mail.nih.gov.
Center for Cancer Research · USNational Cancer Institute · US

Funding

Vaccine and immunotherapy strategies for cancer and viruses causing cancerZIASC004020 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 2009 to 2025
$51.8M
Antigen-specific T-cell activation, vaccines for CancerZ01SC004020 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 1996 to 2008
$3.8M
Intramural NIH HHS Z01 SC004020
6 · The paper itself

Abstract

Mechanisms that imprint T cell homing to the small intestine have been well studied; however, those for homing to the colon are poorly understood. Recently, we found that these are distinct subcompartments of the gut mucosal immune system, which implies differential homing. Here, we show that colonic CD11c

Indexed as

AnimalsAntigen-Presenting CellsCD11c AntigenCD8-Positive T-LymphocytesCell CompartmentationCell MovementCells, CulturedColonDendritic CellsImmunizationIntegrinsIntestinal MucosaIntestine, SmallMice, Inbred C57BLReceptors, CCRReceptors, Lymphocyte HomingCC chemokine receptor 9CD11c Antigenintegrin alpha4beta7IntegrinsReceptors, CCRReceptors, Lymphocyte HomingTretinoinalpha4beta7CCR9gutRALDH

Identifiers

PMID28951425
PMCPMC5669635
OpenAlexW2756859312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.