ArticleBMJ open2017
Evolving landscape of stroke prevention in atrial fibrillation within the UK between 2012 and 2016: a cross-sectional analysis study using CPRD.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non-adherence to Thromboprophylaxis Guidelines in Atrial Fibrillation: A Narrative Review of the Extent of and Factors in Guideline Non-adherence.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Pooled it
- Management of atrial fibrillation for older people with frailty: a systematic review and meta-analysis.Age and ageing · 2019Pooled it
- Supporting anticoagulant treatment decision making to optimise stroke prevention in complex patients with atrial fibrillation: a cluster randomised trial.BMC family practice · 2020Trial
- Prescribing Vitamin-K-Antagonists Versus Direct Oral Anticoagulants Among Bavarian General Practitioners: A Qualitative Study.Health services insights · 2025Article
- Polypharmacy in atrial fibrillation: A prospective analysis of mortality and ischemic stroke using the Clinical Practice Research Datalink.Journal of arrhythmia · 2024Article
- Acquired risk factors and incident atrial fibrillation according to age and genetic predisposition.European heart journal · 2023Article
- Common Cancer Types and Risk of Stroke and Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Population-Based Study in England.Journal of the American Heart Association · 2023Article
- Does coprescribing nonsteroidal anti-inflammatory drugs and oral anticoagulants increase the risk of major bleeding, stroke and systemic embolism?British journal of clinical pharmacology · 2022Article
- Identifying unmet antithrombotic therapeutic need, and implications for stroke and systemic embolism in atrial fibrillation patients: a population-scale longitudinal study.European heart journal open · 2022Article
- Pre- and post-stroke oral antithrombotics and mortality in patients with ischaemic stroke.Pharmacoepidemiology and drug safety · 2022Article
- Impact of oral anticoagulation on the association between frailty and clinical outcomes in people with atrial fibrillation: nationwide primary care records on treatment analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study.PLoS medicine · 2022Article
- Prescribing of direct oral anticoagulants and warfarin to older people with atrial fibrillation in UK general practice: a cohort study.BMC medicine · 2021Article
- Demographic, clinical, and functional determinants of antithrombotic treatment in patients with nonvalvular atrial fibrillation.BMC cardiovascular disorders · 2021Observational
- Real-world data on the incidence, mortality, and cost of ischaemic stroke and major bleeding events among non-valvular atrial fibrillation patients in England.Journal of evaluation in clinical practice · 2021Article
- Annual rate of newly treated atrial fibrillation by age and gender in France, 2010-2016.European journal of epidemiology · 2020Article
- World Café approach: exploring the future vision of oral anticoagulants for patients with atrial fibrillation (AF) in Ireland.BMJ open · 2020Article
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the changes in prescribing of oral anticoagulant (AC) and antiplatelet (AP) agents in patients with non-valvular atrial fibrillation (NVAF) in the UK and to identify the characteristics associated with deviation from guideline-based recommendations.
designFive cross-sectional analyses in a large retrospective population-based cohort study.
settingGeneral practices contributing data to the UK Clinical Practice Research Datalink.
participantsThe study included patients with a diagnosis of NVAF and eligible for anticoagulation (CHA
resultsThe proportion of patients being treated with AC increased at each index date, showing an absolute rise of 16.7% over the study period. At the same time, the proportion of patients treated with an AP alone was reduced by half, showing an absolute decrease of 16.8%. The proportion of patients not receiving any antithrombotic (AT) treatment remained the same across the study period. A number of predictors were identified for AP alone or no treatment compared with AC treatment.
conclusionMajor improvements in the AT management of patients with NVAF for stroke prevention in the UK were observed between April 2012 and January 2016. Despite this, nearly 20% of at-risk patients still received AP alone and over 15% were on no AT agents in January 2016.
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