ArticleMetabolic engineering2017
Fast growth phenotype of E. coli K-12 from adaptive laboratory evolution does not require intracellular flux rewiring.
Article in Metabolic engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Tryptophan metabolism and plant health: mechanisms of action and application prospects.Frontiers in plant science · 2026Pooled it
- Biosynthesis of poly(3-hydroxybutyrate-Biodesign research · 2025Article
- Antimutator and Mutational Spectrum Effects Can Combine to Reduce Evolutionary Potential in Escherichia coli ΔnudJ.Molecular biology and evolution · 2025Article
- Predicting the Rate Structure of an Evolved Metabolic Network.Metabolites · 2025Article
- Model-guided metabolic rewiring to bypass pyruvate oxidation for pyruvate derivative synthesis by minimizing carbon loss.mSystems · 2024Article
- A citric acid cycle-deficient Escherichia coli as an efficient chassis for aerobic fermentations.Nature communications · 2024Article
- Article
- Systems biology of plant metabolic interactions.Journal of biosciences · 2024Review
- HMicroorganisms · 2023Article
- Integrating gene expression data into a genome-scale metabolic model to identify reprogramming during adaptive evolution.PloS one · 2023Article
- Experimental Evolution Reveals Unifying Systems-Level Adaptations but Diversity in Driving Genotypes.mSystems · 2022Article
- Mutants lacking global regulators, fis and arcA, in Escherichia coli enhanced growth fitness under acetate metabolism by pathway reprogramming.Applied microbiology and biotechnology · 2022Article
- Selection for Cell Yield Does Not Reduce Overflow Metabolism in Escherichia coli.Molecular biology and evolution · 2022Article
- Kinetic analysis and modeling of L-valine production in fermentation batch fromBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Bacterial fitness landscapes stratify based on proteome allocation associated with discrete aero-types.PLoS computational biology · 2021Article
- Improved Yield of Recombinant Protein via Flagella Regulator Deletion inFrontiers in microbiology · 2021Article
- Developing rapid growingMetabolic engineering communications · 2020Article
- A quantitative method for proteome reallocation using minimal regulatory interventions.Nature chemical biology · 2020Article
- Rapid Growth and Metabolism of Uropathogenic Escherichia coli in Relation to Urine Composition.Clinical microbiology reviews · 2019Review
- The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology.Metabolic engineering · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Adaptive laboratory evolution (ALE) is a widely-used method for improving the fitness of microorganisms in selected environmental conditions. It has been applied previously to Escherichia coli K-12 MG1655 during aerobic exponential growth on glucose minimal media, a frequently used model organism and growth condition, to probe the limits of E. coli growth rate and gain insights into fast growth phenotypes. Previous studies have described up to 1.6-fold increases in growth rate following ALE, and have identified key causal genetic mutations and changes in transcriptional patterns. Here, we report for the first time intracellular metabolic fluxes for six such adaptively evolved strains, as determined by high-resolution
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Registered trials
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