Evidence map›Paper›PMID 28951260›Full record

ArticleProstaglandins & other lipid mediators2018

Selective inhibition of 20-hydroxyeicosatetraenoic acid lowers blood pressure in a rat model of preeclampsia.

Jessica L Faulkner, Nicole L Plenty, Kedra Wallace, Lorena M Amaral, Mark W Cunningham, Sydney Murphy, Babbette LaMarca

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins & other lipid mediators, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Tracing the Lipid Fingerprints of Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jessica L FaulknerDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Nicole L PlentyDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Kedra WallaceDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Lorena M AmaralDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Mark W CunninghamDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Sydney MurphyDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Babbette LaMarcaDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. Electronic address: bblamarca@umc.edu.
University of Mississippi Medical Center · USState Street (United States) · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
The Kidney, Hypertension, Pregnancy and InflammationR01HD067541 · NICHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI LAMARCA, BABBETTE · 2011 to 2020
$3.1M
Mechanisms of Pregnancy Induced HypertensionF32HL078147 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI LAMARCA, BABBETTE · 2005 to 2007
$149k
NHLBI NIH HHS F32 HL078147NHLBI NIH HHS P01 HL051971NHLBI NIH HHS T32 HL105324NICHD NIH HHS R01 HD067541
6 · The paper itself

Abstract

Little is currently known of the role(s) of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE) in hypertensive pregnancies. We hypothesized that specific inhibition of 20-HETE would attenuate increases in blood pressure in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia. Specific 20-HETE synthesis inhibitor HET0016 (1mg/kg) was administered daily to RUPP rats from gestational days 14-18. Blood pressure (BP) increased in RUPP rats and was decreased with HET0016 administration. BP was unchanged in NP+HET0016 rats. Fetal death greatly increased in RUPP rats and was reduced in RUPP+HET0016 rats. 20-HETE levels increased modestly in RUPP rats compared to NP and was reduced in both NP+HET0016 and RUPP+HET0016 rats. Furthermore, circulating levels of HETEs, EET, and DHETE were significantly altered between groups. HET0016 shifted CYP metabolism toward EETs, as indicated by a decrease in plasma 20-HETE:EETs in RUPP+HET0016 rats compared to RUPP. In conclusion, 20-HETE inhibition in RUPP rats reduces BP and fetal death, and is associated with an increase in EET/20-HETE ratio.

Indexed as

AmidinesAnimalsBlood PressureCytochrome P-450 Enzyme SystemDisease Models, AnimalFemaleHydroxyeicosatetraenoic AcidsPre-EclampsiaPregnancyRats20-hydroxy-5,8,11,14-eicosatetraenoic acidAmidinesCytochrome P-450 Enzyme SystemHET0016Hydroxyeicosatetraenoic Acids20-HETEPlacental ischemiaPreeclampsiaRUPP rat

Identifiers

PMID28951260
PMCPMC5902033
OpenAlexW2760318258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.