ArticleThe Journal of investigative dermatology2018
The Microevolution and Epidemiology of Staphylococcus aureus Colonization during Atopic Eczema Disease Flare.
Article in The Journal of investigative dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Cryptotanshinone inhibitsVirulence · 2026Article
- Whole-genome sequencing to explore genomic profile, pathogenicity, virulence motifs, and pangenome of clinical MRSA isolates.Scientific reports · 2025Article
- High-throughput targeted amplicon screening tool for characterizing intrahost diversity inMicrobial genomics · 2025Article
- Regulation of airway fumarate by host and pathogen promotesbioRxiv : the preprint server for biology · 2025Article
- Multi-strain carriage and intrahost diversity ofMicrobial genomics · 2025Article
- The mutational landscape of Staphylococcus aureus during colonisation.Nature communications · 2025Article
- Article
- Genomic and functional divergence ofMicrobiology spectrum · 2024Article
- Adding Fuel to the Fire? The Skin Microbiome in Atopic Dermatitis.The Journal of investigative dermatology · 2024Review
- Understanding the role ofFrontiers in medicine · 2024Review
- Skin microbiota: pathogenic roles and implications in atopic dermatitis.Frontiers in cellular and infection microbiology · 2024Review
- Investigating genomic diversity ofFrontiers in microbiology · 2024Article
- Review
- Comprehensive Genomic Characterization of Staphylococcus aureus Isolated from Atopic Dermatitis Patients in Japan: Correlations with Disease Severity, Eruption Type, and Anatomical Site.Microbiology spectrum · 2023Article
- Staphylococcus aureus from Atopic Dermatitis Patients: Its Genetic Structure and Susceptibility to Phototreatment.Microbiology spectrum · 2023Article
- The A domain of clonal complex 1-type fibronectin binding protein B promotes adherence and biofilm formation inMicrobiology (Reading, England) · 2023Article
- On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.Cell host & microbe · 2023Article
- Staphylococcal diversity in atopic dermatitis from an individual to a global scale.Cell host & microbe · 2023Article
- Molecular Assessment of Staphylococcus Aureus Strains in STAT3 Hyper-IgE Syndrome Patients.Journal of clinical immunology · 2022Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Staphylococcus aureus is an opportunistic pathogen and variable component of the human microbiota. A characteristic of atopic eczema (AE) is colonization by S. aureus, with exacerbations associated with an increased bacterial burden of the organism. Despite this, the origins and genetic diversity of S. aureus colonizing individual patients during AE disease flares is poorly understood. To examine the microevolution of S. aureus colonization, we deep sequenced S. aureus populations from nine children with moderate to severe AE and 18 non-atopic children asymptomatically carrying S. aureus nasally. Colonization by clonal S. aureus populations was observed in both AE patients and control participants, with all but one of the individuals carrying colonies belonging to a single sequence type. Phylogenetic analysis showed that disease flares were associated with the clonal expansion of the S. aureus population, occurring over a period of weeks to months. There was a significant difference in the genetic backgrounds of S. aureus colonizing AE cases versus controls (Fisher exact test, P = 0.03). Examination of intra-host genetic heterogeneity of the colonizing S. aureus populations identified evidence of within-host selection in the AE patients, with AE variants being potentially selectively advantageous for intracellular persistence and treatment resistance.
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