ArticleAmerican journal of surgery2017
The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen.
Article in American journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Pooled it
- Risk factors for recurrence of chronic subdural hematoma after surgical evacuation: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Uncovering potential biomarkers for chronic kidney disease of unknown etiology through a network-based bioinformatic approach.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
- Coagulation is associated with renal function decline and chronic kidney disease in people living with HIV in South Africa.Frontiers in nephrology · 2026Article
- Association of Complement Factor D with Cardiovascular Mortality and Clot Lysis in CKD.Journal of the American Society of Nephrology : JASN · 2025Article
- Changes in Protein Expression of Renal Drug Transporters and Drug-Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients.Clinical pharmacology and therapeutics · 2025Article
- A Rare Case Report of Wunderlich Syndrome in a Chronic Hemodialysis Patient.Reports (MDPI) · 2025Article
- Anticoagulation in Patients with End-Stage Renal Disease: A Critical Review.Healthcare (Basel, Switzerland) · 2025Review
- A Retrospective Comparative Study of Nerve-Stimulator Versus Ultrasound-Guided Supraclavicular Brachial Plexus Block.Journal of pharmacy & bioallied sciences · 2025Article
- Variability in Coagulation Profiles in Patients with Chronic Kidney Disease and Peripheral Artery Disease.Annals of vascular surgery · 2025Article
- Unveiling the role of sex in the metabolism of indoxyl sulfate and apixaban.Scientific reports · 2025Article
- The impact of chronic kidney disease on prognosis in acute stroke: unraveling the pathophysiology and clinical complexity for optimal management.Clinical and experimental nephrology · 2025Review
- Fibrinogen glycosylation and glycation: molecular insights into thrombosis and vascular disease.Frontiers in molecular biosciences · 2025Review
- Observational
- A comprehensive exploration of chronic kidney disease and dialysis in Canada's Indigenous population: from epidemiology to genetic influences.International urology and nephrology · 2024Review
- Association of chronic kidney disease with postoperative outcomes: a national surgical quality improvement program (NSQIP) multi-specialty surgical cohort analysis.BMC nephrology · 2024Article
- Spontaneous bleeding in chronic kidney disease: global coagulation assays may predict bleeding risk.Research and practice in thrombosis and haemostasis · 2024Article
- Effect of Aspirin Use on the Adverse Outcomes in Patients Hospitalized for COVID-19.Cardiology research · 2024Article
- Complications and Mortality After Surgery in Patients with Chronic Kidney Disease: A Retrospective Cohort Study Based on a Multicenter Clinical Database.Journal of multidisciplinary healthcare · 2024Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChronic kidney disease (CKD) patients have increased rates of bleeding as well as thrombosis. Fibrinogen and platelets combine to generate a mature clot, but in CKD platelets are dysfunctional. Therefore, we hypothesize that CKD patients have increased clot strength due to elevated fibrinogen levels.
methodsRetrospective review of CKD patients (n = 84) who had rTEG and fibrinogen levels measured. They were compared to healthy controls (n = 134).
resultsCKD patients had statistically significant increases in ACT, angle, MA and decreases in LY30 compared to controls. Fibrinogen levels were increased in CKD patients compared to reference range. Fibrinogen levels had a positive correlation with MA (rho = 0.709, p < 0.0001) in CKD patients.
conclusionsPatients with CKD manifest a coagulopathy consisting of delayed clot formation, but increased final clot strength and decreased clot breakdown. Furthermore, the elevated clot strength is mediated by increased fibrinogen levels in CKD patients.
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