ArticleBiological psychiatry2018
Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study.
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Comorbidity of epilepsy and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- Epilepsy and attention-deficit/hyperactivity disorder in children and adolescents: An overview of etiology, prevalence, and treatment.Frontiers in human neuroscience · 2023Pooled it
- Stimulant and non-stimulant drug therapy for people with attention deficit hyperactivity disorder and epilepsy.The Cochrane database of systematic reviews · 2022Pooled it
- The association between ADHD and physical health: a co-twin control study.Scientific reports · 2020Trial
- Transfer learning enhances clinical utility of polygenic scores with small, phenotypically refined cohorts.Genome research · 2026Article
- Familial Clustering of Hypochondriasis.Psychotherapy and psychosomatics · 2026Article
- Screening Results and Performance of the CBCL Using a two-step Procedure for Mental Disorders in Chinese Children and Adolescents: a five-year Survey.The Psychiatric quarterly · 2025Article
- Clinical and sociodemographic predictors of depressive symptoms in epilepsy patients in a single tertiary epilepsy center.Acta neurologica Belgica · 2025Article
- Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects.General psychiatry · 2024Article
- Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder.Frontiers in pediatrics · 2024Review
- The association between early childhood onset epilepsy and attention-deficit hyperactivity disorder (ADHD) in 3237 children and adolescents with Autism Spectrum Disorder (ASD): a historical longitudinal cohort data linkage study.European child & adolescent psychiatry · 2023Article
- Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges.International journal of molecular sciences · 2023Review
- Interventions for ADHD in children & adolescents with epilepsy: A review and decision tree to guide clinicians.Epilepsy & behavior : E&B · 2022Review
- Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study.Diabetes care · 2022Article
- Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder.JAMA network open · 2022Article
- Medical conditions and Attention-Deficit/Hyperactivity Disorder symptoms from early childhood to adolescence.Molecular psychiatry · 2022Article
- Maternal epilepsy- perinatal outcome and long-term neurological morbidity of the offspring: a population-based cohort study.Archives of gynecology and obstetrics · 2022Article
- Familial liability to asthma and ADHD: A Swedish national register-based study.JCPP advances · 2021Article
- The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder.Neuroscience and biobehavioral reviews · 2021Review
- Mapping phenotypic and aetiological associations between ADHD and physical conditions in adulthood in Sweden: a genetically informed register study.The lancet. Psychiatry · 2021Article
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundEpilepsy and attention-deficit/hyperactivity disorder (ADHD) are strongly associated; however, the underlying factors contributing to their co-occurrence remain unclear. A shared genetic liability has been proposed as one possible mechanism. Therefore, our goal in this study was to investigate the familial coaggregation of epilepsy and ADHD and to estimate the contribution of genetic and environmental risk factors to their co-occurrence.
methodsWe identified 1,899,654 individuals born between 1987 and 2006 via national Swedish registers and linked each individual to his or her biological relatives. We used logistic regression to estimate the association between epilepsy and ADHD within individual and across relatives. Quantitative genetic modeling was used to decompose the cross-disorder covariance into genetic and environmental factors.
resultsIndividuals with epilepsy had a statistically significant increased risk of ADHD (odds ratio [OR] = 3.47, 95% confidence interval [CI] = 3.33-3.62). This risk increase extended to children whose mothers had epilepsy (OR = 1.85, 95% CI = 1.75-1.96), children whose fathers had epilepsy (OR = 1.64, 95% CI = 1.54-1.74), full siblings (OR = 1.56, 95% CI = 1.46-1.67), maternal half siblings (OR = 1.28, 95% CI = 1.14-1.43), paternal half siblings (OR = 1.10, 95% CI = 0.96-1.25), and cousins (OR = 1.15, 95% CI = 1.10-1.20). The genetic correlation was 0.21 (95% CI = 0.02-0.40) and explained 40% of the phenotypic correlation between epilepsy and ADHD, with the remaining variance largely explained by nonshared environmental factors (49%, nonshared environmental correlation = 0.36, 95% CI = 0.23-0.49). The contribution of shared environmental factors to the cross-disorder overlap was not statistically significant (11%, shared environmental correlation = 0.32, 95% CI = -0.16-0.79).
conclusionsThis study demonstrates a strong and etiologically complex association between epilepsy and ADHD, with shared familial factors and risk factors unique to the individual contributing to co-occurrence of the disorders. Our findings suggest that epilepsy and ADHD may share less genetic risk as compared with other neurodevelopmental disorders.
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