Evidence map›Paper›PMID 28950941›Full record

ReviewExperimental eye research2017

Ocular surface inflammation impairs structure and function of meibomian gland.

Shin Mizoguchi, Hiroki Iwanishi, Reiko Arita, Kumi Shirai, Takayoshi Sumioka, Masahide Kokado, James V Jester, Shizuya Saika

Open access · greenAbstract readReview
In one paragraph

Review in Experimental eye research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Novel Rabbit Model of Meibomian Gland Dysfunction-Induced Dry Eye.Translational vision science & technology · 2025
    Article
  9. Meibomian gland atrophy in children with allergic conjunctivitis.International journal of ophthalmology · 2025
    Article
  10. Review
  11. Observational
  12. Article
  13. Urban Particulate Matter Triggers Meibomian Gland Dysfunction.Investigative ophthalmology & visual science · 2024
    Article
  14. Article
  15. Meibomian Gland Dysfunction Clinical Practice Guidelines.Japanese journal of ophthalmology · 2023
    Article
  16. Article
  17. Review
  18. The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice.International journal of molecular sciences · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Shin MizoguchiDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Hiroki IwanishiDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan. Electronic address: iwanishi@wakayama-med.ac.jp.
Reiko AritaItoh Clinic, Saitama, Japan.
Kumi ShiraiDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Takayoshi SumiokaDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Masahide KokadoDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
James V JesterGavin Herbert Eye Institute, University of California, Irvine, USA.
Shizuya SaikaDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Wakayama Medical University · JPItochu (Japan) · JPUniversity of California, Irvine · US

Funding

Age-Related Meibomian Gland DysfunctionR01EY021510 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI James V Jester · 2011 to 2026
$4.8M
NEI NIH HHS R01 EY021510
6 · The paper itself

Abstract

Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson's syndrome or chemical burning of the ocular surface and lid margin.

Indexed as

Conjunctival DiseasesContact LensesCorneal EdemaCytokinesEpithelium, CornealEyelid DiseasesHumansMeibomian GlandsTearsCytokinesChemical burnConjunctivitisContact lensMeibomian glandOcular surface inflammationRosacea

Identifiers

PMID28950941
PMCPMC5914509
OpenAlexW2759617848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.