ArticleFluids and barriers of the CNS2017
Characterization of cardiac- and respiratory-driven cerebrospinal fluid motion based on asynchronous phase-contrast magnetic resonance imaging in volunteers.
Article in Fluids and barriers of the CNS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 68 citations in OpenAlex.
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- Human cerebrospinal fluid net flow enhanced by respiration during the awake state.Nature communications · 2025Article
- Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans-Similarities and Differences from Animal Models.Journal of molecular neuroscience : MN · 2025Review
- Modeling dynamic inflow effects in fMRI to quantify cerebrospinal fluid flow.bioRxiv : the preprint server for biology · 2025Article
- Assessing the feasibility of a new approach to measure the full spectrum of cerebrospinal fluid dynamics within the human brain using MRI: insights from a simulation study.Interface focus · 2025Article
- A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.Fluids and barriers of the CNS · 2025Review
- Modeling dynamic inflow effects in fMRI to quantify cerebrospinal fluid flow.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate.Brain multiphysics · 2024Article
- Paediatric pineal region cysts: enigma or impaired neurofluid system?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Metformin Alleviates Delayed Hydrocephalus after Intraventricular Hemorrhage by Inhibiting Inflammation and Fibrosis.Translational stroke research · 2023Article
- Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.Fluids and barriers of the CNS · 2022Review
- Cerebrovascular activity is a major factor in the cerebrospinal fluid flow dynamics.NeuroImage · 2022Article
- Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space.AJNR. American journal of neuroradiology · 2022Article
- Spatial and temporal variation of routine parameters: pitfalls in the cerebrospinal fluid analysis in central nervous system infections.Journal of neuroinflammation · 2022Review
- Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.Neuropathology and applied neurobiology · 2022Article
- Evaluation of Cardiac- and Respiratory-driven Cerebrospinal Fluid Motions by Applying the S-transform to Steady-state Free Precession Phase Contrast Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Deep breathing couples CSF and venous flow dynamics.Scientific reports · 2022Article
- The glymphatic hypothesis: the theory and the evidence.Fluids and barriers of the CNS · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA classification of cardiac- and respiratory-driven components of cerebrospinal fluid (CSF) motion has been demonstrated using echo planar imaging and time-spatial labeling inversion pulse techniques of magnetic resonance imaging (MRI). However, quantitative characterization of the two motion components has not been performed to date. Thus, in this study, the velocities and displacements of the waveforms of the two motions were quantitatively evaluated based on an asynchronous two-dimensional (2D) phase-contrast (PC) method followed by frequency component analysis.
methodsThe effects of respiration and cardiac pulsation on CSF motion were investigated in 7 healthy subjects under guided respiration using asynchronous 2D-PC 3-T MRI. The respiratory and cardiac components in the foramen magnum and aqueduct were separated, and their respective fractions of velocity and amount of displacement were compared.
resultsFor velocity in the Sylvian aqueduct and foramen magnum, the fraction attributable to the cardiac component was significantly greater than that of the respiratory component throughout the respiratory cycle. As for displacement, the fraction of the respiratory component was significantly greater than that of the cardiac component in the aqueduct regardless of the respiratory cycle and in the foramen magnum in the 6- and 10-s respiratory cycles. There was no significant difference between the fractions in the 16-s respiratory cycle in the foramen magnum.
conclusionsTo separate cardiac- and respiratory-driven CSF motions, asynchronous 2D-PC MRI was performed under respiratory guidance. For velocity, the cardiac component was greater than the respiratory component. In contrast, for the amount of displacement, the respiratory component was greater.
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