ArticleAtherosclerosis2017
Leukocyte telomere length and cardiovascular disease in African Americans: The Jackson Heart Study.
Article in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis.BioMed research international · 2019Pooled it
- Pooled it
- The association of mean telomere length with all-cause, cerebrovascular and cardiovascular mortality.Bioscience reports · 2019Trial
- Hypertension and epigenetic aging: socio-biological pathways of health disparity.Clinical epigenetics · 2026Article
- Telomere length as a biomarker for cerebrovascular diseases: current evidence.Molecular biology reports · 2024Review
- Association Between Prenatal Exposure to Organochlorine Pesticides and Telomere Length in Neonatal Cord Blood.Toxics · 2024Article
- The association between SII and aging: evidence from NHANES 1999-2018.Frontiers in public health · 2024Article
- New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death.International journal of molecular sciences · 2023Review
- Association between life's essential 8 and biological ageing among US adults.Journal of translational medicine · 2023Article
- Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.Scientific reports · 2023Article
- Causal relationships between telomere length and liver disease: a Mendelian randomization study.Frontiers in genetics · 2023Article
- Variability in newborn telomere length is explained by inheritance and intrauterine environment.BMC medicine · 2022Observational
- Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.Cell genomics · 2022Article
- Effect of dietary inflammatory potential on the aging acceleration for cardiometabolic disease: A population-based study.Frontiers in nutrition · 2022Article
- Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis.Frontiers in nutrition · 2022Article
- Telomere length and the risk of cardiovascular diseases: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study.Healthcare (Basel, Switzerland) · 2021Article
- Prognostic Association of TERC, TERT Gene Polymorphism, and Leukocyte Telomere Length in Acute Heart Failure: A Prospective Study.Frontiers in endocrinology · 2021Article
- Genetics and geography of leukocyte telomere length in sub-Saharan Africans.Human molecular genetics · 2020Article
- The relationship between neighborhood socioeconomic deprivation and telomere length: The 1999-2002 National Health and Nutrition Examination Survey.SSM - population health · 2020Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsIn European descent populations, shorter leukocyte telomere length (LTL) has been associated with subclinical atherosclerosis, cardiovascular disease (CVD), and mortality, while longer LTL has been associated with greater left ventricular hypertrophy. We evaluated the relationship of LTL with subclinical cardiovascular disease indices and incident clinical events and mortality in African Americans (AAs).
methodsAnalyses were restricted to 2518 participants of the Jackson Heart Study (JHS) with LTL measured by Southern blot in baseline blood samples.
resultsAdjusting for established CVD risk factors, longer LTL was significantly associated with lower prevalence of coronary artery calcification (CAC) (odds ratio (OR) = 0.810) per 1 kb increase in LTL; (95% confidence interval [CI] 0.656, 0.9998), p=0.0498). Longer LTL was also associated with higher ankle brachial index (ABI) (β = 0.023; (95% CI 0.004, 0.042), p=0.017) when comparing the highest to the lowest LTL quartile. There were no significant associations between LTL and abdominal aortic calcification, carotid intima-media thickness, or left ventricular mass. After a median follow-up of 9 years, longer LTL was associated with lower risk of incident ischemic stroke (hazard ratio (HR) 0.69 (95% CI 0.48, 0.99), p=0.044) and total mortality (HR 0.81 (95% CI 0.67, 0.97), p=0.026) in age and sex adjusted models, but these associations were no longer significant in fully adjusted models.
conclusionsAmong a community-based cohort of AAs, longer LTL was nominally associated with lower odds of CAC and increased ABI, indicative of decreased prevalence of subclinical atherosclerosis and peripheral arterial disease. These findings do not offer strong support for LTL as an independent biomarker of CVD risk in AAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.