Evidence map›Paper›PMID 28949995›Full record

ArticlePloS one2017

Implementing an isoniazid preventive therapy program for people living with HIV in Thailand.

Junya Danyuttapolchai, Somyot Kittimunkong, Sriprapa Nateniyom, Sutthapa Painujit, Virat Klinbuayaem, Nuanpun Maipanich, Yongyut Maokamnerd, Eric Pevzner, Sara Whitehead, Apiratee Kanphukiew and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Junya DanyuttapolchaiThailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi province, Thailand.ORCID http://orcid.org/0000-0003-1895-8295
Somyot KittimunkongBureau of Vector-Borne Diseases, Department of Disease Control, Thailand Ministry of Public Health, Nonthaburi province, Thailand.
Sriprapa NateniyomBureau of Tuberculosis, Department of Disease Control, Thailand Ministry of Public Health, Bangkok, Thailand.
Sutthapa PainujitNakhon Si Thammarat Hospital, Nakhon Si Thammarat Province, Thailand.
Virat KlinbuayaemSanpatong Hospital, Chiang Mai Province, Thailand.
Nuanpun MaipanichVachira Phuket Hospital, Phuket Province, Thailand.
Yongyut MaokamnerdSomdejprajaotaksin Maharaj Hospital, Tak Province, Thailand.
Eric PevznerU. S. Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Sara WhiteheadThailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi province, Thailand.
Apiratee KanphukiewThailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi province, Thailand.
Patama MonkongdeeThailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi province, Thailand.
Michael MartinThailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi province, Thailand.
Ministry of Public Health · THCenters for Disease Control and Prevention · USNakhon Si Thammarat Rajabhat University · THSanPaTong Hospital · THVachira Phuket Hospital · TH

Funding

CGH CDC HHS U19 GH000004
6 · The paper itself

Abstract

Treatment of people living with HIV (PLHIV) with latent tuberculosis (TB) infection using isoniazid preventive therapy (IPT) can reduce the risk of TB disease, however, the scale-up of IPT among PLHIV in Thailand and worldwide has been slow. To hasten the implementation of IPT in Thailand, we developed IPT implementation training curricula and tools for health care providers and implemented IPT services in seven large government hospitals. Of the 659 PLHIV enrolled, 272 (41.3%) reported symptoms of TB and 39 (14.3% of those with TB symptoms) were diagnosed with TB. A total of 346 (52.4%) participants were eligible for IPT; 318 (91.9%) of these participants opted to have a tuberculin skin test (TST) and 52 (16.3% of those who had a TST) had a positive TST result. Among the 52 participants with a positive TST, 46 (88.5%) initiated and 39 (75.0%) completed 9 months of IPT: physicians instructed three participants to stop IPT, two participants were lost to follow-up, one chose to stop therapy, and one developed TB. IPT can be implemented among PLHIV in Thailand and could reduce the burden of TB in the country.

Indexed as

AdolescentAdultAntitubercular AgentsFemaleHIV InfectionsHumansIsoniazidMaleThailandTuberculosisAntitubercular AgentsIsoniazid

Identifiers

PMID28949995
PMCPMC5614535
OpenAlexW2757014142

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.