ArticleThe Journal of general virology2017
A lethal model of disseminated dengue virus type 1 infection in AG129 mice.
Article in The Journal of general virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability.Animal models and experimental medicine · 2026Article
- A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage.Emerging microbes & infections · 2025Article
- A lethal DENV-2 wild-type mouse model for mutagenesis investigations.BMC biology · 2025Article
- Mouse models as a tool to study asymptomatic DENV infections.Frontiers in cellular and infection microbiology · 2025Review
- Progress and challenges in development of animal models for dengue virus infection.Emerging microbes & infections · 2024Review
- mRNA-encoded Cas13 can be used to treat dengue infections in mice.Nature microbiology · 2024Article
- Electropenetrography with Alternating Current Reveals In Situ Changes ofComparative medicine · 2024Article
- The Dynamic Relationship between Dengue Virus and the Human Cutaneous Innate Immune Response.Viruses · 2024Review
- Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections.PLoS pathogens · 2024Article
- Transient Blockade of Type I Interferon Signalling Promotes Replication of Dengue Virus Strain D2Y98P in Adult Wild-Type Mice.Viruses · 2023Article
- Flying under the radar - impact and factors influencing asymptomatic DENV infections.Frontiers in cellular and infection microbiology · 2023Review
- A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice.Virologica Sinica · 2022Article
- GluiScience · 2022Article
- Mammalian animal models for dengue virus infection: a recent overview.Archives of virology · 2022Review
- Evaluation ofViruses · 2021Article
- Immunomodulatory Activities ofPathogens (Basel, Switzerland) · 2021Article
- Tree Shrew as a New Animal Model for the Study of Dengue Virus.Frontiers in immunology · 2021Article
- Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery.Frontiers in pharmacology · 2021Review
- Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models.EBioMedicine · 2020Article
- Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue.The American journal of tropical medicine and hygiene · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The mosquito-borne disease dengue is caused by four serologically and genetically related flaviviruses termed DENV-1 to DENV-4. Dengue is a global public health concern, with both the geographical range and burden of disease increasing rapidly. Clinically, dengue ranges from a relatively mild self-limiting illness to a severe life-threatening and sometimes fatal disease. Infection with one DENV serotype produces life-long homotypic immunity, but incomplete and short-term heterotypic protection. The development of small-animal models that recapitulate the characteristics of the disseminated disease seen clinically has been difficult, slowing the development of vaccines and therapeutics. The AG129 mouse (deficient in interferon alpha/beta and gamma receptor signalling) has proven to be valuable for this purpose, with the development of models of disseminated DENV-2,-3 and -4 disease. Recently, a DENV-1 AG129 model was described, but it requires antibody-dependent enhancement (ADE) to produce lethality. Here we describe a new AG129 model utilizing a non-mouse-adapted DENV-1 strain, West Pacific 74, that does not require ADE to induce lethal disease. Following high-titre intraperitoneal challenge, animals experience a virus infection with dissemination to multiple visceral tissues, including the liver, spleen and intestine. The animals also become thrombocytopenic, but vascular leakage is less prominent than in AG129 models with other DENV serotypes. Taken together, our studies demonstrate that this model is an important addition to dengue research, particularly for understanding the pathological basis of the disease between DENV serotypes and allowing the full spectrum of activity to test comparisons for putative vaccines and antivirals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.