ArticleTranslational psychiatry2017
Dietary fish, n-3 polyunsaturated fatty acid consumption, and depression risk in Japan: a population-based prospective cohort study.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Fish Consumption and the Risk of Depression: A Systematic Review and Meta-Analysis of Observational Studies.Nutrients · 2025Pooled it
- Nutrition and Healthy Ageing in Asia: A Systematic Review.Nutrients · 2023Pooled it
- Effect of High Ratio of n-6/n-3 PUFAs on Depression: A Meta-Analysis of Prospective Studies.Frontiers in nutrition · 2022Pooled it
- Evidence of the Importance of Dietary Habits Regarding Depressive Symptoms and Depression.International journal of environmental research and public health · 2020Pooled it
- The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders.Nutrients · 2019Pooled it
- Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial.Nutrients · 2018Trial
- Article
- Article
- A longitudinal metabolomics study on blood mercury and depressive symptoms.Scientific reports · 2025Article
- Impact of eating alone and nutrient intake on psychological distress among older Japanese adults: A cross-sectional study.Asia Pacific journal of clinical nutrition · 2025Article
- Adherence to the Mediterranean Diet and Risk of Depression: A Cohort Study in Chinese Community Residents.Nutrients · 2025Article
- Article
- Association of serum fatty acid pattern with depression in U.S. adults: analysis of NHANES 2011-2012.Lipids in health and disease · 2024Article
- Higher adherence to a Mediterranean-type diet is associated with reduced psychosocial stress levels in baby boomers: a cross-sectional study.Nutrition research and practice · 2024Article
- Relationship between food group-specific intake and depression among local government employees in Japan.BMC nutrition · 2024Article
- Increased intake of marine fish contributed to a decreased odds of comorbid depressive symptoms and coronary heart disease in Chinese adults.Frontiers in nutrition · 2024Article
- Association between plasma polyunsaturated fatty acids and depressive among US adults.Frontiers in nutrition · 2024Article
- The association between midlife living arrangement and psychiatrist-diagnosed depression in later life: who among your family members reduces the risk of depression?Translational psychiatry · 2022Article
- The Lifelong Health Support 10: a Japanese prescription for a long and healthy life.Environmental health and preventive medicine · 2022Review
- Maternal active asthma in pregnancy influences associations between polyunsaturated fatty acid intake and child asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systematic review of observational studies has revealed that fish consumption and levels of n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid are associated with a reduced risk of depression. A reverse J-shaped effect of n-3 PUFAs was suggested. However, there is limited evidence from populations with high fish consumption and no studies have used a standard psychiatrist-based diagnosis of major depressive disorder (MDD). Therefore, this population-based, prospective study investigated the association of dietary fish, n-3 PUFA, and n-6 PUFA consumption with risk of psychiatrist-diagnosed MDD in Japan. A total of 12 219 subjects were enrolled from the Saku area in 1990. Of these, we extracted 1181 participants aged 63-82 years who completed food frequency questionnaires in both 1995 and 2000 and also underwent a mental health examination in 2014-2015. Odds ratios (ORs) and 95% confidence intervals (CIs) for MDD according to fish intake and PUFA quartiles were calculated. Current MDD was diagnosed in 95 patients. We found a reduced risk of MDD in the third quartile for fish intake (111.1 g per day, OR=0.44, 95% CI=0.23-0.84), second quartile for EPA (307.7 mg per day, OR=0.54, 95% CI=0.30-0.99) and third quartile for docosapentaenoic acid (DPA) (123.1 mg per day, OR=0.42, 95% CI=0.22-0.85). ORs adjusted for cancer, stroke, myocardial infarction and diabetes remained significant for fish and DPA intake. Our results suggest that moderate fish intake could be recommended for the prevention of MDD in aged Japanese individuals.
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