Evidence map›Paper›PMID 28949271›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury.

Subhabrata Mitra, Gemma Bale, David Highton, Roxanna Gunny, Cristina Uria-Avellanal, Alan Bainbridge, Magdalena Sokolska, David Price, Angela Huertas-Ceballos, Giles S Kendall and 3 more

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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  15. Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Observational
  16. Article
  17. Article
  18. A bright forecast for autoregulation monitoring?The Journal of physiology · 2018
    Article
  19. Article
  20. MAESTROS: A Multiwavelength Time-Domain NIRS System to Monitor Changes in Oxygenation and Oxidation State of Cytochrome-C-Oxidase.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Subhabrata Mitra1 Institute for Women's Health, University College London, London, UK.
Gemma Bale2 Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
David Highton3 Neurocritical Care, National Hospital for Neurology & Neurosurgery, University College London, London, UK.
Roxanna Gunny4 Paediatric Neuroradiology, Great Ormond Street Hospital for Children, London, UK.
Cristina Uria-Avellanal1 Institute for Women's Health, University College London, London, UK.
Alan Bainbridge5 Department of Medical Physics and Biomedical Engineering, University College London Hospital, London, UK.
Magdalena Sokolska5 Department of Medical Physics and Biomedical Engineering, University College London Hospital, London, UK.
David Price5 Department of Medical Physics and Biomedical Engineering, University College London Hospital, London, UK.
Angela Huertas-Ceballos6 Neonatal Unit, University College London Hospital, London, UK.
Giles S Kendall6 Neonatal Unit, University College London Hospital, London, UK.
Judith Meek1 Institute for Women's Health, University College London, London, UK.
Ilias Tachtsidis2 Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Nicola J Robertson1 Institute for Women's Health, University College London, London, UK.
University College London · GBUniversity College Hospital · GBLondon Women's Clinic · GBNational Hospital for Neurology and Neurosurgery · GB

Funding

Department of HealthWellcome Trust 088429/Z/09/ZWellcome Trust 104580/Z/14/Z
6 · The paper itself

Abstract

Hypoxic ischemic encephalopathy (HIE) leads to significant morbidity and mortality. Impaired autoregulation after hypoxia-ischaemia has been suggested to contribute further to injury. Thalamic lactate/N-Acetylasperate (Lac/NAA) peak area ratio of > 0.3 on proton (

Indexed as

Adenosine TriphosphateAspartic AcidBlood PressureBrainCerebrovascular CirculationDevelopmental DisabilitiesElectron Transport Complex IVFemaleHomeostasisHumansHypoxia-Ischemia, BrainInfant, NewbornLactic AcidMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleAdenosine TriphosphateAspartic AcidElectron Transport Complex IVLactic AcidN-acetylaspartatecerebral autoregulationcerebral hemodynamicsmetabolismnear infrared spectroscopyPerinatal hypoxia

Identifiers

PMID28949271
PMCPMC6311664
OpenAlexW2757302240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.