Evidence map›Paper›PMID 28949051›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2017

Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected women.

Brian M O Ogendi, Rakesh K Bakshi, Steffanie Sabbaj, LaDraka' Brown, Jeannette Y Lee, Richa Kapil, William M Geisler

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. UnveilingiScience · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Brian M O OgendiDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Rakesh K BakshiDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Steffanie SabbajDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
LaDraka' BrownDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jeannette Y LeeDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Richa KapilDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
William M GeislerDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-0603-2404
University of Alabama at Birmingham · USUniversity of Arkansas for Medical Sciences · US

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
UAB Center for Clinical and Translational Science (CCTS) UL1UL1TR000165 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2012 to 2013
$9.6M
Mechanisms and Correlates of Immune Protection against Genital Chlamydia in HumansR01AI093692 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GEISLER, WILLIAM M · 2012 to 2023
$4.5M
Midcareer Mentoring Award for Patient-Oriented Research in Chlamydia trachomatis InfectionK24AI125685 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAM M GEISLER · 2016 to 2026
$1.3M
NCATS NIH HHS UL1 TR000165NCATS NIH HHS UL1 TR001417NIAID NIH HHS K24 AI125685NIAID NIH HHS R01 AI093692
6 · The paper itself

Abstract

problemDifferences in circulating (peripheral) and mucosal T-cell phenotypes in chlamydia-infected women remain largely unknown. METHOD OF STUDY: Thirteen paired mononuclear cell specimens from blood and cervicovaginal lavages collected from chlamydia-infected women were stained and analyzed using ten-color cell surface flow cytometry for T-cell distribution, activation status, homing, and T helper (Th)-associated chemokine receptors (CKRs).

resultsA higher proportion of genital mucosal T-cells were activated (CD38

conclusionT-cell phenotypes differed in the peripheral vs genital mucosa compartments in chlamydia-infected women. As chlamydia infects mucosal epithelial cells, the finding of a higher frequency of activated T-cells and Th-1 phenotypes in the mucosa likely reflects an adaptive immune response to infection.

Indexed as

Adaptive ImmunityAdultAnimalsBlood CellsCell SeparationChlamydiaChlamydia InfectionsFemaleFlow CytometryHumansImmunophenotypingLymphocyte ActivationMiceMucous MembranePhenotypeTh1 CellsChlamydiamucosalperipheralphenotypereceptorT-cell

Identifiers

PMID28949051
PMCPMC5681419
OpenAlexW2757029604

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.