Evidence map›Paper›PMID 28948913›Full record

ArticleeLife2017

Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in

R Blake Billmyre, Shelly Applen Clancey, Joseph Heitman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 91 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Distinct evolutionary trajectories following loss of RNA interference inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Distinct evolutionary trajectories following loss of RNA interference inbioRxiv : the preprint server for biology · 2024
    Article
  11. Review
  12. Importance of theJournal of fungi (Basel, Switzerland) · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. CryptoCEN: A Co-Expression Network forbioRxiv : the preprint server for biology · 2023
    Article
  17. A Landscape of the Genomic Structure ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  18. Journal of fungi (Basel, Switzerland) · 2022
    Article
  19. Article
  20. Recent insights into the evolution of mutation rates in yeast.Current opinion in genetics & development · 2022
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

R Blake BillmyreDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Duke University Medical Center, Durham, United States.ORCID 0000-0003-4866-3711
Shelly Applen ClanceyDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Duke University Medical Center, Durham, United States.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Duke University Medical Center, Durham, United States.
Duke University · US

Funding

ORGANIZATION AND FUNCTIONS OF CELLULAR STRUCTUREST32GM007184 · NIGMS · DUKE UNIVERSITY · PI JINKS-ROBERTSON, SUE · 1985 to 2019
$18.2M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R37 AI039115NIGMS NIH HHS T32 GM007184
6 · The paper itself

Abstract

Pathogenic microbes confront an evolutionary conflict between the pressure to maintain genome stability and the need to adapt to mounting external stresses. Bacteria often respond with elevated mutation rates, but little evidence exists of stable eukaryotic hypermutators in nature. Whole genome resequencing of the human fungal pathogen

Indexed as

Biological Variation, PopulationCodon, NonsenseDrug Resistance, FungalCryptococcusFungal ProteinsMutation RateMutS Homolog 2 ProteinWhole Genome SequencingCodon, NonsenseFungal ProteinsMutS Homolog 2 ProteinCryptococcus deuterogattiiCryptococcus gattiievolutionary biologygenomicshomopolymershypermutatorinfectious diseasemicrobiologyphenotypic diversity

Identifiers

PMID28948913
PMCPMC5614558
OpenAlexW2618931295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.