Evidence map›Paper›PMID 28948540›Full record

SynthesisJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2018

Diagnostic and prognostic significance of transient ischemic dilation (TID) in myocardial perfusion imaging: A systematic review and meta-analysis.

Mohamed Alama, Christopher Labos, Handel Emery, Robert M Iwanochko, Michael Freeman, Mansoor Husain, Douglas S Lee

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Transient ischemic dilation ratio by [The international journal of cardiovascular imaging · 2025
    Article
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  12. Quality metrics for single-photon emission computed tomography myocardial perfusion imaging: an ASNC information statement.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Prognostic value of absent left ventricular ejection fraction reserve with regadenoson SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  17. Prognostic value of early left ventricular ejection fraction reserve during regadenoson stress solid-state SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  18. Article
  19. The evolution of the prognostic value of regadenoson SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  20. Changes in left ventricle myocardial volume during stress test using cadmium-zinc-telluride cardiac imaging: Implications in coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mohamed AlamaDivision of Cardiology, Peter Munk Cardiac Center and the Joint Department of Medical Imaging, Toronto, Canada.
Christopher LabosInstitute for Clinical Evaluative Sciences, Toronto, Canada.
Handel EmeryUniversity of the West Indies, Kingston, Jamaica.
Robert M IwanochkoDivision of Cardiology, Peter Munk Cardiac Center and the Joint Department of Medical Imaging, Toronto, Canada.
Michael FreemanSt. Michael's Hospital, Toronto, Canada.
Mansoor HusainDivision of Cardiology, Peter Munk Cardiac Center and the Joint Department of Medical Imaging, Toronto, Canada.
Douglas S LeeDivision of Cardiology, Peter Munk Cardiac Center and the Joint Department of Medical Imaging, Toronto, Canada. dlee@ices.on.ca.
University of Toronto · CAInstitute for Clinical Evaluative Sciences · CAUniversity of the West Indies · JM

Funding

CIHR FDN 148446
6 · The paper itself

Abstract

backgroundTransient ischemic dilatation (TID) of the left ventricle is a potential marker of high risk obstructive coronary artery disease on stress myocardial perfusion imaging (MPI). There is, however, interstudy variation in the diagnostic performance of TID for identification of severe and extensive coronary disease anatomy, and varied prognostic implications in the published literature.

methodsWe searched MEDLINE, EMBASE, and COCHRANE databases for studies where TID was compared with invasive or CT coronary angiography for evaluation of coronary artery stenosis. Two reviewers independently evaluated and abstracted data from each study. A bivariate random effects model was used to derive pooled sensitivities and specificities, in order to account for correlation between TID in MPI and anatomic disease severity.

resultsA total of 525 articles were reviewed, of which 51 met inclusion criteria. Thirty-one studies contributed to the analysis, representing a total of 2037 patients in the diagnostic meta-analysis and 9003 patients in the review of prognosis. The ratio above which TID was deemed present ranged from 1.13 to 1.38. Pooled sensitivity was 44% (95% CI 30%-60%) and specificity was 88% (95% CI 83%-92%) for the detection of extensive or severe anatomic coronary artery disease. Analysis of outcome data demonstrated increased cardiac event rates in patients with TID and an abnormal MPI. In otherwise normal perfusion, TID is an indicator of poor prognosis in patients with diabetes and/or a history of coronary disease.

conclusionsAmong patients undergoing MPI, the presence of TID is specific for the detection of extensive or severe coronary artery disease.

Indexed as

Myocardial Perfusion ImagingDilatation, PathologicHeart VentriclesHumansMyocardial IschemiaPrognosisdiagnostic and prognostic applicationoutcomes researchSPECT

Identifiers

PMID28948540
PMCPMC5966496
OpenAlexW2760394644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.