ReviewCurrent treatment options in oncology2017
Rectal Cancer in Asian vs. Western Countries: Why the Variation in Incidence?
Review in Current treatment options in oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Feasibility of robotic surgery in elderly patients with rectal cancer: a meta-analysis.Journal of robotic surgery · 2025Pooled it
- Development of the 'PREDICT' score through a systematic review and meta-analysis of the predictive parameters for locoregional recurrence after total mesorectal excision.Updates in surgery · 2021Pooled it
- Article
- Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8Annals of medicine · 2025Article
- Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs.Chemical reviews · 2025Review
- Radiotherapy volume delineation based on MRI andAbdominal radiology (New York) · 2025Article
- Age-Period-Cohort Analysis on the Burden of Gastrointestinal Cancers in China: Trends, Risk Factors, and Predictions.Healthcare (Basel, Switzerland) · 2025Article
- Recurrence patterns and management of locally recurrent rectal cancer: a retrospective cohort study.Langenbeck's archives of surgery · 2025Article
- Truly Inevitable-Our Perspective on the Complications After Surgery for Rectal Cancer.Indian journal of surgical oncology · 2025Article
- Combined neoadjuvant chemotherapy and immunotherapy in a hepatitis B virus-positive patient with locally advanced rectal adenocarcinoma: a case report and literature review.Frontiers in oncology · 2025Article
- Prognosis and clinicopathological features of patients with early-onset and late-onset colorectal cancer with second primary malignancies.Journal of gastroenterology and hepatology · 2025Article
- Perinatal Famine Exposure and Young-Onset Cancer-Lessons from China Health and Nutrition Survey.Cancers · 2024Article
- Determinants of survival and recurrence in patients with stage I colorectal cancer.Frontiers in surgery · 2024Article
- Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics.Cell reports. Medicine · 2023Article
- Prediction of p53 mutation status in rectal cancer patients based on magnetic resonance imaging-based nomogram: a study of machine learning.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Features and outcomes of rectal cancer patients treated in a hospital in Bogotá, Colombia: a retrospective cohort study.Scientific reports · 2023Article
- Analysis of factors associated with postoperative acute kidney injury in patients with colorectal cancer and the development of a risk prediction model: a retrospective study.Updates in surgery · 2023Article
- The mortality risk in patients with early onset colorectal cancer: the role of comorbidities.Frontiers in oncology · 2023Article
- Modifiable lifestyle factors have a larger contribution to colorectal neoplasms than family history.BMC cancer · 2022Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
opinion statementColorectal cancer (CRC) is the third most common cancer worldwide. CRC has been thought to be less common in Asia compared to Western countries. However, the incidence rates of CRC in Asia are high and there is an increasing trend in the Asian population. Furthermore, colorectal cancer accounts for the greatest number of all incidences of CRC in Asia. The increasing adoption of a Western lifestyle, particularly in dietary habits, is likely the most important factor contributing to the rapid increase in colon cancer incidence; it is noteworthy that trends for rectal cancer were flat. The etiology of colon and rectal cancer is a bit different. The risks of distal colon and rectal cancers are more likely to be related to environmental factors, such as polluted surface water sources, alcohol consumption, and habitual smoking. The lack of great change in the incidence of rectal cancer might be due to weaker associations with such lifestyle factors. Therefore, it has been hypothesized that proximal and distal sections of the colon and rectum are two different organs in terms of function and genetic background. It may mean differences in differential sensitivities and exposures to carcinogens. However, despite the decrease in whole incidence, the CRC incidence in young adults in Western countries are reversely increasing, especially in rectal cancer, due to reasons largely unknown. Although the treatment algorithm is different between Asia and western countries, globally, the survival rate for patients with rectal cancer has risen during the past 10 years. Screening contributes a great deal to reducing the incidence and improving survival. Most countries in Asia, such as China, need nationwide registration and screening systems to provide better data.
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