ArticleInternational journal of legal medicine2018
Evaluation of the inclusion of circular RNAs in mRNA profiling in forensic body fluid identification.
Article in International journal of legal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Application of RNA markers in forensic body fluid analysis: from specificity and stability to polymorphism.International journal of legal medicine · 2026Review
- Gene regulation by non-Coding RNAs in infertility: a mechanistic review.Journal of ovarian research · 2025Review
- Emerging roles of exosomal circRNAs in non-small cell lung cancer.Journal of translational medicine · 2025Review
- Circular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology/diseases.European journal of medical research · 2024Review
- Integrative lncRNA, circRNA, and mRNA analysis reveals expression profiles of six forensic body fluids/tissue.International journal of legal medicine · 2024Article
- Research progress and potential application of microRNA and other non-coding RNAs in forensic medicine.International journal of legal medicine · 2024Review
- Identification of Mixtures of Two Types of Body Fluids Using the Multiplex Methylation System and Random Forest Models.Current medical science · 2023Article
- The potential of using non-coding RNAs in forensic science applications.Forensic sciences research · 2023Review
- Establishment of a co-analysis system for personal identification and body fluid identification: a preliminary report.International journal of legal medicine · 2022Article
- On the Identification of Body Fluids and Tissues: A Crucial Link in the Investigation and Solution of Crime.Genes · 2021Review
- Recent research progress on circular RNAs: Biogenesis, properties, functions, and therapeutic potential.Molecular therapy. Nucleic acids · 2021Review
- Evaluation of one-step RT-PCR multiplex assay for body fluid identification.International journal of legal medicine · 2021Article
- CircSLC8A1 and circNFIX can be used as auxiliary diagnostic markers for sudden cardiac death caused by acute ischemic heart disease.Scientific reports · 2021Article
- Circular RNAs in Sudden Cardiac Death Related Diseases: Novel Biomarker for Clinical and Forensic Diagnosis.Molecules (Basel, Switzerland) · 2021Review
- Association between circular RNA expression content and severity of coronary atherosclerosis in human coronary artery.Journal of clinical laboratory analysis · 2020Article
- Quantitative analysis of noncoding RNA from paired fresh and formalin-fixed paraffin-embedded brain tissues.International journal of legal medicine · 2020Article
- Detection and discrimination of seminal fluid using attenuated total reflectance Fourier transform infrared (ATR FT-IR) spectroscopy combined with chemometrics.International journal of legal medicine · 2020Article
- Distinct spectrum of microRNA expression in forensically relevant body fluids and probabilistic discriminant approach.Scientific reports · 2019Article
- Characterization of tissue-specific biomarkers with the expression of circRNAs in forensically relevant body fluids.International journal of legal medicine · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
The use of messenger RNA (mRNA) profiling is considered a promising method in the identification of forensically relevant body fluids which can provide crucial information for reconstructing a potential crime. However, casework samples are usually of limited quantity or have been subjected to degradation, which requires improvement of body fluid identification. Circular RNAs (circRNAs), a class of products from the backsplicing of pre-mRNAs, are shown to have high abundance, remarkable stability, and cell type-specific expression in human cells. In this study, we investigated whether the inclusion of circRNAs in mRNA profiling improve the detection of biomarkers including δ-aminolevulinate synthase 2 (ALAS2) and matrix metallopeptidase 7 (MMP7) in body fluid identification. The major circRNAs of ALAS2 and MMP7 were first identified and primer sets for the simultaneous detection of linear and circular transcripts were developed. The inclusion of circRNAs in mRNA profiling showed improved detection sensitivity and stability of biomarkers revealed by using serial dilutions, mixed samples, and menstrual bloodstains as well as degraded and aged samples. Therefore, the inclusion of circRNAs in mRNA profiling should facilitate the detection of mRNA markers in forensic body fluid identification.
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