Evidence map›Paper›PMID 28948350›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2017

Diagnostic accuracy of an artificial neural network compared with statistical quantitation of myocardial perfusion images: a Japanese multicenter study.

Kenichi Nakajima, Takashi Kudo, Tomoaki Nakata, Keisuke Kiso, Tokuo Kasai, Yasuyo Taniguchi, Shinro Matsuo, Mitsuru Momose, Masayasu Nakagawa, Masayoshi Sarai and 5 more

Abstract readMulticenter Study
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
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  17. Machine learning-based risk model usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kenichi NakajimaKanazawa University Hospital, Kanazawa, Japan. nakajima@med.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0001-7188-8746
Takashi KudoNagasaki University Hospital, Nagasaki, Japan.
Tomoaki NakataHakodate Goryoukaku Hospital, Hakodate, Japan.
Keisuke KisoNational Cerebral and Cardiovascular Center, Suita, Japan.
Tokuo KasaiTokyo Medical University Hachioji Medical Center, Hachioji, Japan.
Yasuyo TaniguchiHyogo Brain and Heart Center, Himeji, Japan.
Shinro MatsuoKanazawa University Hospital, Kanazawa, Japan.
Mitsuru MomoseTokyo Women's Medical University, Tokyo, Japan.
Masayasu NakagawaAkita City Hospital, Akita, Japan.
Masayoshi SaraiFujita Health University Hospital, Toyoake, Japan.
Satoshi HidaTokyo Medical University Hospital, Tokyo, Japan.
Hirokazu TanakaTokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Kunihiko YokoyamaPublic Central Hospital of Matto Ishikawa, Hakusan, Japan.
Koichi OkudaKanazawa Medical University, Uchinada, Kahoku, Japan.
Lars EdenbrandtUniversity of Gothenburg, Gothenburg, Sweden.

Funding

JSPS Grants-in-Aid for Scientific Research 15K09947
6 · The paper itself

Abstract

purposeArtificial neural networks (ANN) might help to diagnose coronary artery disease. This study aimed to determine whether the diagnostic accuracy of an ANN-based diagnostic system and conventional quantitation are comparable.

methodsThe ANN was trained to classify potentially abnormal areas as true or false based on the nuclear cardiology expert interpretation of 1001 gated stress/rest

resultsThe ANN generated a better area under the ROC curves (AUC) than SSS (0.92 vs. 0.82, p < 0.0001), indicating better identification of stress defects. The ANN also generated a better AUC than SDS (0.90 vs. 0.75, p < 0.0001) for stress-induced ischemia. The AUC for patients with old myocardial infarction based on rest defects was 0.97 (0.91 for SRS, p = 0.0061), and that for patients with and without a history of revascularization based on stress defects was 0.94 and 0.90 (p = 0.0055 and p < 0.0001 vs. SSS, respectively). The SSS/SRS/SDS steeply increased when ANN values (probability of abnormality) were >0.80.

conclusionThe ANN was diagnostically accurate in various clinical settings, including that of patients with previous myocardial infarction and coronary revascularization. The ANN could help to diagnose coronary artery disease.

Indexed as

Myocardial Perfusion ImagingNeural Networks, ComputerStatistics as TopicAgedFemaleHumansImage Processing, Computer-AssistedJapanMaleROC CurveArtificial intelligenceComputer-aided diagnosisCoronary artery diseaseDiagnostic imagingNuclear cardiology

Identifiers

PMID28948350
PMCPMC5680364

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.