Evidence map›Paper›PMID 28948210›Full record

ArticleeNeuro

NCS-Rapgef2, the Protein Product of the Neuronal

Sunny Zhihong Jiang, Wenqin Xu, Andrew C Emery, Charles R Gerfen, Maribeth V Eiden, Lee E Eiden

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Rare heterozygous de novo variants in RAPGEF2 are associated with a neurodevelopmental disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Familial adult myoclonic epilepsy (FAME): clinical features, molecular characteristics, pathophysiological aspects and diagnostic work-up.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. What's New in Endocrinology: The Chromaffin Cell.Frontiers in endocrinology · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 3 countries.

Sunny Zhihong JiangSection on Molecular Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20892.ORCID 0000-0002-0706-1581
Wenqin XuSection on Molecular Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20892.ORCID 0000-0001-8813-8183
Andrew C EmerySection on Molecular Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20892.ORCID 0000-0002-6760-2570
Charles R GerfenLaboratory of Systems Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20892.
Maribeth V EidenSection on Directed Gene Transfer Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20892.
Lee E EidenSection on Molecular Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20892.
National Institute of Mental Health · US

Funding

Chemical Coding Of NeurotransmissionZIAMH002386 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, LEE E. · 2009 to 2025
$25.6M
Functional Organization Of The Cerebral Cortex and Basal GangliaZIAMH002497 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI GERFEN, CHARLES R · 2009 to 2025
$18.3M
Viral And Cellular Factors Governing Efficient Gene DeliveryZIAMH002592 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, MARIBETH V. · 2009 to 2015
$7.9M
NEUROSECRETORY VESICLED PROTEINS AND CHEMICAL CODING OF NEUROTRANSMISSIONZ01MH002386 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, LEE E. · 1987 to 2008
$3.6M
Viral &Cellular Factors Governing Retroviral InfectionZ01MH002592 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, MARIBETH V. · 1991 to 2008
$2.6M
Intramural NIH HHS Z01 MH002386Intramural NIH HHS Z01 MH002592NIMH NIH HHS ZIA MH002386NIMH NIH HHS ZIA MH002592
6 · The paper itself

Abstract

The neuritogenic cAMP sensor (NCS), encoded by the

Indexed as

AnimalsBrainCell Line, TransformedCyclic AMPExtracellular Signal-Regulated MAP KinasesGene Expression RegulationGreen Fluorescent ProteinsGuanine Nucleotide Exchange FactorsHumansMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeuroblastomaNeuronsPC12 CellsCyclic AMPExtracellular Signal-Regulated MAP KinasesGreen Fluorescent ProteinsGuanine Nucleotide Exchange FactorsNerve Tissue ProteinsRAPGEF2 protein, humanReceptors, Dopamine D1RNA, MessengeramphetaminecAMPcell signalingcocaineGPCRMAP kinasepsycho-stimulants

Identifiers

PMID28948210
PMCPMC5611689
OpenAlexW2755586266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.