Evidence map›Paper›PMID 28948139›Full record

ReviewJournal of bone oncology2017

The role of biomarkers in the management of bone-homing malignancies.

Stella D'Oronzo, Janet Brown, Robert Coleman

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of bone oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Prognostic value of serum estradiol and sclerostin for predicting fracture healing in postmenopausal women with osteoporotic vertebral compression fractures.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  10. The numerous facets of 1q21Oncology letters · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Stella D'OronzoAcademic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Whitham Road, Sheffield S10 2S, England, UK.
Janet BrownAcademic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Whitham Road, Sheffield S10 2S, England, UK.
Robert ColemanAcademic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Whitham Road, Sheffield S10 2S, England, UK.
University of Sheffield · GBWeston Park Cancer Centre · GB

Funding

Cancer Research UK 10048Department of Health 09/91/21
6 · The paper itself

Abstract

Bone represents a common site of metastasis from several solid tumours, including breast, prostate and lung malignancies. The onset of bone metastases (BM) is associated not only with serious skeletal complications, but also shortened overall survival, owing to the lack of curative treatment options for late-stage cancer. Despite the diagnostic advances, BM detection often occurs in the symptomatic stage, underlining the need for novel strategies aimed at the early identification of high-risk patients. To this purpose, both bone turnover and tumour-derived markers are being investigated for their potential diagnostic, prognostic and predictive roles. In this review, we summarize the pathogenesis of BM in breast, prostate and lung tumours, while exploring the current research focused on the identification and clinical validation of BM biomarkers.

Indexed as

1CTP, cross-linked carboxy-terminal telopeptide of type 1 collagenBALP, bone specific alkaline phosphataseBC, breast cancerBiomarkersBM, bone metastasesBMDC, bone marrow derived cellsBMPs, bone morphogenetic proteinsBone metastasisBone turnover markersBreast cancerBSP, bone sialoproteinBTA, bone-targeting agentsBTM, bone turnover markersCAPG, macrophage-capping proteinCaSR, calcium sensing receptorCCL2, chemokine C-C ligand 2CTC, circulating tumour cellsCXCL, C–X–C motif chemokine ligandCXCR, C–X–C motif chemokine receptorDPD, deoxypyridinolineDTC, disseminated tumour cellsEMT, epithelial to mesenchymal transitionER, estrogen receptorFGF, fibroblast growth factorGIPC1, PDZ domain–containing protein member 1Her2, human epidermal growth factor receptor 2HR, hormone receptorIGF, insulin-like growth factorIL-1R, IL-1 receptorIL, interleukinLC, lung cancerLung cancerMAF, v-maf avian musculo-aponeurotic fibrosarcoma oncogene homologM-CSF, macrophage colony stimulating factormiRNA, micro RNANSCLC, non-small cell LCNTX and CTX, N- and C- telopeptides of type 1 collagenOPG, osteoprotegerinP1NP and P1CP, N and C terminal pro-peptides of type 1 collagenPC, prostate cancerPDGF, platelet-derived growth factorPDGFRα, PDGF receptor αPlGF, placental growth factorProstate cancerPSA, prostate specific antigenPTH, parathyroid hormonePTH-rP, PTH related proteinPYD, pyridinolineRANK-L, RANK-ligandRANK, receptor activator of nuclear factor kBsBALP, serum BALPSDF-1, stromal cell-derived factor 1shRNA, short hairpin RNASREs, skeletal related eventsTGF-β, transforming growth factor-βTNF, tumour necrosis factorTRACP-5b, tartrate-resistant acid phosphatase type 5bTRAF3, TNF receptor associated factor 3uNTX, urinary NTXVEGF, vascular endothelial growth factorZNF217, zinc-finger protein 217β-CTX, CTX β isomer

Identifiers

PMID28948139
PMCPMC5602513
OpenAlexW2756028197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.