ArticleCurrent bladder dysfunction reports2017
The Aging Overactive Bladder: A Review of Aging-Related Changes from the Brain to the Bladder.
Article in Current bladder dysfunction reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Global Prevalence of Overactive Bladder: A Systematic Review and Meta-analysis.International urogynecology journal · 2025Pooled it
- Pooled it
- Randomized trial of transcutaneous tibial nerve stimulation to treat overactive bladder in older women.PloS one · 2026Trial
- Efficacy of salt reduction for managing overactive bladder symptoms: a prospective study in patients with excessive daily salt intake.Scientific reports · 2021Trial
- Neurogenic lower urinary tract dysfunction in ageing men with spinal cord injury.Nature reviews. Urology · 2026Review
- Ice Water Test Unmasks Detrusor Overactivity in Apparently Normal Conventional Cystometry.European urology open science · 2026Article
- Comparative Analysis of 3-Year Reintervention Rates for Rezum vs. UroLift: A TriNetX Study.International journal of urology : official journal of the Japanese Urological Association · 2026Article
- PIEZO1-mediated mechanosensation links aging to bladder dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Tackling the progression of benign prostatic hyperplasia/benign prostatic obstruction progression: Deobstructing within the "window of curability" (a hypothesis-generating review).Current urology · 2025Article
- The mechanism of action of neuromodulation in the treatment of overactive bladder.Nature reviews. Urology · 2025Review
- Neurotrophins and Proneurotrophins as Biomarkers for Overactive Bladder Syndrome in Aging Females.Metabolites · 2025Article
- The use of intradetrusor botulinum toxin in the geriatric population.BJUI compass · 2025Article
- Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice.Current research in toxicology · 2025Article
- A 7-tesla study of cerebellar alterations relating to bladder control in women with multiple sclerosis voiding dysfunction using functional connectivity.Clinical neuroimaging (Hoboken, N.J.) · 2025Article
- Protocol for a Series of Systematic Reviews and Network Meta-analyses of Randomized Controlled Trials of Medications for Patients with Overactive Bladder Symptoms.European urology open science · 2024Article
- Quantification of Aging-Related Decreases in Sensory Innervation of the Bladder Trigone in Rats.International neurourology journal · 2024Article
- Article
- Polychlorinated biphenyl (PCB) exposure in adult female mice can influence bladder contractility.American journal of clinical and experimental urology · 2023Article
- Effects of Aging and Gender on the Anorectal Function of Healthy Subjects Assessed with Conventional Anorectal Manometry.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Article
- Third-line therapy for overactive bladder in the elderly: Nuances and considerations.Neurourology and urodynamics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewTo understand the current literature on age-related neural and detrusor changes associated with overactive bladder symptoms. RECENT
findingsRecent functional magnetic resonance imaging (fMRI) studies have unveiled an age-related decrease in the neural control of continence, represented in the insula, anterior cingulate cortex (ACC) and prefrontal cortex (PFC). Older individuals with overactive bladder symptoms also demonstrate heightened activation of the ACC with low volumes, representing increased bladder sensitivity or sense of urgency. At the level of the bladder, age-related changes in the urothelium, neurotransmitters/receptors (both muscarinic and purinergic), and inflammation [including nerve growth factor (NGF), monocyte chemoattractant protein-1 (MCP-1) and oxidative stress] are also associated with overactive bladder. SUMMARY: Overactive bladder among older adults is a complex condition incorporating physiologic age-related changes from the brain to the bladder and beyond.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.