Evidence map›Paper›PMID 28947856›Full record

ArticleJournal of polymer science. Part A, Polymer chemistry2017

Oxygen-mediated Polymerization Initiated by Oltipraz-derived Thiones.

Scott R Zavada, Joseph C Furgal, Nathan D Wood, Timothy F Scott

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of polymer science. Part A, Polymer chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Scott R ZavadaMacromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI 48109-2136, USA.
Joseph C FurgalDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109-2136, USA.
Nathan D WoodDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109-2136, USA.
Timothy F ScottMacromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI 48109-2136, USA.
University of Michigan–Ann Arbor · USInstitute of Macromolecular Chemistry · UA

Funding

Oxygen-Mediated Initiation of Thiol-ene Adhesives and SealantsR21EB011761 · NIBIB · UNIVERSITY OF COLORADO · PI BOWMAN, CHRISTOPHER N · 2010 to 2011
$388k
NIBIB NIH HHS R21 EB011761
6 · The paper itself

Abstract

A pyrrolopyrazine-thione derived from oltipraz, a compound that has been investigated as a chemopreventive agent, affords radicals in the presence of thiols and oxygen via a redox cycle, an attribute that suggests its suitability as an initiator for oxygen-mediated polymerization. Here, we explore the utilization of this pyrrolopyrazine-thione, generated in situ from a precursor, as an initiator for the radical-mediated thiol-ene polymerization. While the pyrrolopyrazine-thione was shown to be capable of generating radicals in the presence of atmospheric oxygen and thiol groups, the reaction extents achievable were lower than desired owing to the presence of unwanted side reactions that would quench radical production and, subsequently, suppress polymerization. Moreover, we found that complex interactions between the pyrrolopyrazine-thione, its precursor, oxygen, and thiol groups determine whether or not the quenching reaction dominates over those favorable to polymerization.

Identifiers

PMID28947856
PMCPMC5609726
OpenAlexW2586616704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.