Evidence map›Paper›PMID 28947825›Full record

Observational studyInternational journal of obesity (2005)2018

Untargeted metabolomics identifies a plasma sphingolipid-related signature associated with lifestyle intervention in prepubertal children with obesity.

M J Leal-Witt, M Ramon-Krauel, S Samino, M Llobet, D Cuadras, J C Jimenez-Chillaron, O Yanes, C Lerin

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

M J Leal-WittDepartment of Endocrinology, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
M Ramon-KrauelDepartment of Endocrinology, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
S SaminoMetabolomics Platform, Department of Electronic Engineering (DEEEA), Universitat Rovira i Virgili, Tarragona, Spain.
M LlobetDepartment of Endocrinology, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
D CuadrasDepartment of Statistics, Sant Joan de Déu Research Foundation, Barcelona, Spain.
J C Jimenez-ChillaronDepartment of Endocrinology, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
O YanesMetabolomics Platform, Department of Electronic Engineering (DEEEA), Universitat Rovira i Virgili, Tarragona, Spain.
C LerinDepartment of Endocrinology, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0003-0950-4363
Hospital Sant Joan de Déu Barcelona · ESCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESSant Joan de Déu Research Foundation · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChildhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metabolic signatures associated with lifestyle intervention in prepubertal children with obesity.

methodsThirty-five prepubertal children (7-10 years) with obesity (body mass index (BMI)>2 standard deviations) were enrolled in the study and participated in a 6-month-long lifestyle intervention program. Physiological and biochemical data and blood samples were collected both at baseline and after the intervention. A liquid chromatography-mass spectrometry (LC-MS)-based metabolomics approach was applied to obtain a comprehensive profiling of plasma samples, identifying 2581 distinct metabolite. Principal component analysis (PCA) was performed to consolidate all features into 8 principal components. Associations between metabolites and physiological and biochemical variables were investigated.

resultsThe intervention program significantly decreased mean (95% CI) BMI standard deviation score from 3.56 (3.29-3.84) to 3.11 (2.88-3.34) (P<0.001). PCA identified one component (PC1) significantly altered by the intervention (Bonferroni adjusted P=0.008). A sphingolipid metabolism-related signature was identified as the major contributor to PC1. Sphingolipid metabolites were decreased by the intervention, and included multiple sphingomyelin, ceramide, glycosylsphingosine and sulfatide species. Changes in several sphingolipid metabolites were associated with intervention-induced improvements in HbA1c levels.

conclusionsDecreased circulating sphingolipid-related metabolites were associated with lifestyle intervention in prepubertal children with obesity, and correlated to improvements in HbA1c.

Indexed as

Life StyleChildFemaleGlycated HemoglobinHumansMaleMetabolomeMetabolomicsPediatric ObesitySphingolipidsGlycated Hemoglobinhemoglobin A1c protein, humanSphingolipids

Identifiers

PMID28947825
OpenAlexW2747594331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.