ArticleScientific reports2017
Metagenomic-based Surveillance of Pacific Coast tick Dermacentor occidentalis Identifies Two Novel Bunyaviruses and an Emerging Human Ricksettsial Pathogen.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 58 citations in OpenAlex.
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- Metagenomic and serological evidence of emerging tick-borne viruses in livestock, humans, and rats in Pakistan.Virologica Sinica · 2026Article
- Alongshan virus in the virome of Ixodes hexagonus ticks in the United Kingdom.Ticks and tick-borne diseases · 2026Article
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- Orientia, Rickettsia, and the microbiome in rodent attached chiggers in North Carolina, USA.PloS one · 2024Article
- Characterisation of putative novel tick viruses and zoonotic risk prediction.Ecology and evolution · 2024Article
- Metagenomic surveillance for bacterial tick-borne pathogens using nanopore adaptive sampling.Scientific reports · 2023Article
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- Virome analysis of ticks in Zhoushan Archipelago, China.The Journal of veterinary medical science · 2022Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
An increasing number of emerging tick-borne diseases has been reported in the United States since the 1970s. Using metagenomic next generation sequencing, we detected nucleic acid sequences from 2 novel viruses in the family Bunyaviridae and an emerging human rickettsial pathogen, Rickettsia philipii, in a population of the Pacific Coast tick, Dermacentor occidentalis in Mendocino County sampled annually from 2011 to 2014. A total of 250 adults of this human-biting, generalist tick were collected from contiguous chaparral and grassland habitats, and RNA from each individually extracted tick was deep sequenced to an average depth of 7.3 million reads. We detected a Francisella endosymbiont in 174 ticks (70%), and Rickettsia spp. in 19 ticks (8%); Rickettsia-infected ticks contained R. rhipicephali (16 of 250, 6.4%) or R. philipii (3 of 250,1.2%), the agent of eschar-associated febrile illness in humans. The genomes of 2 novel bunyaviruses (>99% complete) in the genera Nairovirus and Phlebovirus were also identified and found to be present in 20-91% of ticks, depending on the year of collection. The high prevalence of these bunyaviruses in sampled Dermacentor ticks suggests that they may be viral endosymbionts, although further studies are needed to determine whether they are infectious for vertebrate hosts, especially humans, and their potential role in tick ecology.
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