ArticleScientific reports2017
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Glycation-Driven Mitochondrial and ER Stress Underlies Iodoacetic Acid-Induced Apoptosis in Porcine Uterus and Oviduct Epithelial Cells.Antioxidants (Basel, Switzerland) · 2026Article
- Progress in research on DDOST dysregulation in related diseases.Glycoconjugate journal · 2025Review
- Convergent Evolution and Predictability of Gene Copy Numbers Associated with Diets in Mammals.Genome biology and evolution · 2025Article
- An immune-related multi-omics analysis of dolichyl-diphosphooligosaccharide protein glycosyltransferase in glioma: Prognostic value exploration and competitive endogenous RNA network identification.IET systems biology · 2023Article
- Identification of a Novel Prognostic Signature Based on N-Linked Glycosylation and Its Correlation with Immunotherapy Response in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2023Article
- Research Trends in Advanced Glycation End Products and Obesity: Bibliometric Analysis.Nutrients · 2022Article
- Exposure ofNutrients · 2021Article
- Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure.iScience · 2021Article
- The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).Endocrinology, diabetes & metabolism · 2021Article
- Prognostic Biomarker DDOST and Its Correlation With Immune Infiltrates in Hepatocellular Carcinoma.Frontiers in genetics · 2021Article
- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.Handbook of experimental pharmacology · 2021Article
- AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes.The Journal of clinical investigation · 2020Article
- Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.Scientific reports · 2019Article
- RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease.International journal of endocrinology · 2019Review
- Mechanistic targeting of advanced glycation end-products in age-related diseases.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
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Authors and funding
17 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protein oligosaccharyltransferase-48 (OST48) is integral to protein N-glycosylation in the endoplasmic reticulum (ER) but is also postulated to act as a membrane localised clearance receptor for advanced glycation end-products (AGE). Hepatic ER stress and AGE accumulation are each implicated in liver injury. Hence the objective of this study was to increase the expression of OST48 and examine the effects on hepatic function and structure. Groups of 8 week old male mice (n = 10-12/group) over-expressing the gene for OST48, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST+/-), were followed for 24 weeks, while randomised to diets either low or high in AGE content. By week 24 of the study, either increasing OST48 expression or consumption of high AGE diet impaired liver function and modestly increased hepatic fibrosis, but their combination significantly exacerbated liver injury in the absence of steatosis. DDOST+/- mice had increased both portal delivery and accumulation of hepatic AGEs leading to central adiposity, insulin secretory defects, shifted fuel usage to fatty and ketoacids, as well as hepatic glycogen accumulation causing hepatomegaly along with hepatic ER and oxidative stress. This study revealed a novel role of the OST48 and AGE axis in hepatic injury through ER stress, changes in fuel utilisation and glucose intolerance.
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