Evidence map›Paper›PMID 28947754›Full record

ArticleScientific reports2017

Morphologically normalized left ventricular motion indicators from MRI feature tracking characterize myocardial infarction.

Paolo Piras, Luciano Teresi, Paolo Emilio Puddu, Concetta Torromeo, Alistair A Young, Avan Suinesiaputra, Pau Medrano-Gracia

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A Statistical Shape Model Approach for Computing Left Ventricle Volume and Ejection Fraction Using Multi-plane Ultrasound Images.VipIMAGE 2019 : proceedings of the VII ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, October 16-18, 2019, Porto, Portugal. VipIMAGE (Conference) (2019 : Porto, Portugal) · 2019
    Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paolo PirasDipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Via del Policlinico 155, 00186, Roma, Italy.
Luciano TeresiDipartimento di Matematica e Fisica, LaMS-Modeling & Simulation Lab, Via della Vasca Navale 84, Università Roma Tre, Roma, 00146, Roma, Italy.ORCID 0000-0002-5178-8120
Paolo Emilio PudduDipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Via Eudossiana 18, 00184, Roma, Italy. paoloemilio.puddu@uniroma1.it.ORCID 0000-0002-6191-7838
Concetta TorromeoDipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Via Eudossiana 18, 00184, Roma, Italy.
Alistair A YoungDepartment of Anatomy and Medical Imaging, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.
Avan SuinesiaputraDepartment of Anatomy and Medical Imaging, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.ORCID 0000-0003-1165-458X
Pau Medrano-GraciaDepartment of Anatomy and Medical Imaging, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.

Funding

The Cardiac Atlas ProjectR01HL121754 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D., OMENS, JEFFREY H. · 2014 to 2023
$5.0M
The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.R01HL087773 · NHLBI · UNIVERSITY OF AUCKLAND · PI YOUNG, ALISTAIR ANDREW · 2008 to 2010
$1.4M
NHLBI NIH HHS R01 HL087773NHLBI NIH HHS R01 HL121754
6 · The paper itself

Abstract

We characterized motion attributes arising from LV spatio-temporal analysis of motion distributions in myocardial infarction. Time-varying 3D finite element shape models were obtained in 300 Controls and 300 patients with myocardial infarction. Inter-individual left ventricular shape differences were eliminated using parallel transport to the grand mean of all cases. The first three principal component (PC) scores were used to characterize trajectory attributes. Scores were tested with ANOVA/MANOVA using patient disease status (Infarcts vs. Controls) as a factor. Infarcted patients had significantly different magnitude, orientation and shape of left ventricular trajectories in comparison to Controls. Significant differences were found for the angle between PC scores 1 and 2 in the endocardium, and PC scores 1 and 3 in the epicardium. The largest differences were found in the magnitude of endocardial motion. Endocardial PC scores in shape space showed the highest classification power using support vector machine, with higher total accuracy in comparison to previous methods. Shape space performed better than size-and-shape space for both epicardial and endocardial features. In conclusion, LV spatio-temporal motion attributes accurately characterize the presence of infarction. This approach is easily generalizable to different pathologies, enabling more precise study of the pathophysiological consequences of a wide spectrum of cardiac diseases.

Indexed as

MotionHeart VentriclesHumansImaging, Three-DimensionalMagnetic Resonance ImagingMyocardial InfarctionSpatio-Temporal Analysis

Identifiers

PMID28947754
PMCPMC5612925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.