ArticleScientific reports2017
Exploitation of a newly-identified entry pathway into the malaria parasite-infected erythrocyte to inhibit parasite egress.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The inner membrane complex protein, IMC55, is dispensable for intraerythrocytic development ofMicrobiology spectrum · 2026Article
- Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress.PLoS pathogens · 2026Article
- The inner membrane complex protein, IMC55, is dispensable for intra-erythrocytic development ofbioRxiv : the preprint server for biology · 2025Article
- Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug.Nature structural & molecular biology · 2025Article
- An essential endoplasmic reticulum-resident N-acetyltransferase ortholog in Plasmodium falciparum.Journal of cell science · 2023Article
- Dramatic Consequences of Reducing Erythrocyte Membrane Cholesterol on Plasmodium falciparum.Microbiology spectrum · 2022Article
- Liposomes for malaria management: the evolution from 1980 to 2020.Malaria journal · 2021Review
- Unveiling the Sugary Secrets ofFrontiers in microbiology · 2021Review
- Repurposing Heparin as Antimalarial: Evaluation of Multiple Modifications Toward In Vivo Application.Pharmaceutics · 2020Article
- Contacting domains segregate a lipid transporter from a solute transporter in the malarial host-parasite interface.Nature communications · 2020Article
- EXP1 is required for organisation of EXP2 in the intraerythrocytic malaria parasite vacuole.Cellular microbiology · 2020Article
- Characterization of sulfated polysaccharide activity against virulentF1000Research · 2020Article
- EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites.PLoS biology · 2019Article
- Article
- EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX.Nature microbiology · 2018Article
- Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes.Cellular microbiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
While many parasites develop within host cells to avoid antibody responses and to utilize host cytoplasmic resources, elaborate egress processes have evolved to minimize the time between escaping and invading the next cell. In human erythrocytes, malaria parasites perforate their enclosing erythrocyte membrane shortly before egress. Here, we show that these pores clearly function as an entry pathway into infected erythrocytes for compounds that inhibit parasite egress. The natural glycosaminoglycan heparin surprisingly inhibited malaria parasite egress, trapping merozoites within infected erythrocytes. Labeled heparin neither bound to nor translocated through the intact erythrocyte membrane during parasite development, but fluxed into erythrocytes at the last minute of the parasite lifecycle. This short encounter was sufficient to significantly inhibit parasite egress and dispersion. Heparin blocks egress by interacting with both the surface of intra-erythrocytic merozoites and the inner aspect of erythrocyte membranes, preventing the rupture of infected erythrocytes but not parasitophorous vacuoles, and independently interfering with merozoite disaggregation. Since this action of heparin recapitulates that of neutralizing antibodies, membrane perforation presents a brief opportunity for a new strategy to inhibit parasite egress and replication.
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