Evidence map›Paper›PMID 28947646›Full record

ArticleInfection and immunity2018

Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison.

Pauline Maiello, Robert M DiFazio, Anthony M Cadena, Mark A Rodgers, Philana Ling Lin, Charles A Scanga, JoAnne L Flynn

Abstract readComparative Study
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

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  20. Model systems to studyFrontiers in cellular and infection microbiology · 2025
    Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pauline MaielloDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Robert M DiFazioDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Anthony M CadenaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Mark A RodgersDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Philana Ling Lin *Department of Pediatrics, Division of Infectious Diseases, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Charles A Scanga *Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA scangaca@pitt.edu joanne@pitt.edu.
JoAnne L Flynn *Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA scangaca@pitt.edu joanne@pitt.edu.ORCID https://orcid.org/0000-0001-7874-8981

Funding

Autoimmunity and Immunopathology Training ProgramT32AI089443 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2010 to 2024
$6.6M
Predicting immune responses that correlate with protection against tuberculosisR01HL110811 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2012 to 2016
$5.9M
Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
The Impact of Pre-exisiting SIV on Host Immunity to M tuberculosis in MacaquesR01AI111815 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCANGA, CHARLES A. · 2015 to 2019
$3.8M
Predicting protective T-cell responses in Tuberculosis using a systems biology approachR01AI123093 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2016 to 2020
$3.6M
PET Probes Targeting Immune Cells for Imaging TuberculosisR01AI118195 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 2015 to 2019
$3.5M
The Consequences of Reinfection with M. tuberculosisR01AI114674 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., FORTUNE, SARAH · 2015 to 2019
$3.4M
HIV-TB Co-infection: Tracking TB emergence after asymptomatic (latent) infectionR01AI111871 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIN, PHILANA LING · 2014 to 2018
$3.3M
B cells and humoral immunity in tuberculosisR01AI094745 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHAN, JOHN R. · 2012 to 2016
$3.2M
NHLBI NIH HHS R01 HL110811NIAID NIH HHS R01 AI094745NIAID NIH HHS R01 AI111815NIAID NIH HHS R01 AI111871NIAID NIH HHS R01 AI114674NIAID NIH HHS R01 AI118195NIAID NIH HHS R01 AI123093NIAID NIH HHS T32 AI060525NIAID NIH HHS T32 AI089443
6 · The paper itself

Abstract

In the past 2 decades, it has become increasingly clear that nonhuman primates, specifically macaques, are useful models for human tuberculosis (TB). Several macaque species have been used for TB studies, and questions remain about the similarities and differences in TB pathogenesis among macaque species, which can complicate decisions about the best species for a specific experiment. Here we provide a quantitative assessment, using serial positron emission tomography and computed tomography (PET-CT) imaging and precise quantitative determination of bacterial burdens of low-dose

Indexed as

Disease SusceptibilityMacaca fascicularisMacaca mulattaAnimalsBacterial LoadDisease Models, AnimalLungMycobacterium tuberculosisPositron Emission Tomography Computed TomographyTuberculosismacaqueMycobacteriumnonhuman primatePET CTtuberculosis

Identifiers

PMID28947646
PMCPMC5778369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.