Evidence map›Paper›PMID 28947643›Full record

ArticleInfection and immunity2017

Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates.

Alayna K Caffrey-Carr, Caitlin H Kowalski, Sarah R Beattie, Nathan A Blaseg, Chanell R Upshaw, Arsa Thammahong, Hannah E Lust, Yi-Wei Tang, Tobias M Hohl, Robert A Cramer and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  3. Trans-Kingdom dsRNA Sensing:bioRxiv : the preprint server for biology · 2026
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  6. Microorganisms · 2025
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  7. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
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  14. Article
  15. Article
  16. Immunity to pathogenic fungi in the eye.Seminars in immunology · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Alayna K Caffrey-CarrMontana State University, Department of Microbiology and Immunology, Bozeman, Montana, USA.
Caitlin H KowalskiGeisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, New Hampshire, USA.
Sarah R BeattieGeisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, New Hampshire, USA.
Nathan A BlasegMontana State University, Department of Microbiology and Immunology, Bozeman, Montana, USA.
Chanell R UpshawDepartment of Microbiology, Miami University, Oxford, Ohio, USA.
Arsa ThammahongGeisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, New Hampshire, USA.
Hannah E LustGeisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, New Hampshire, USA.
Yi-Wei TangDepartment of Laboratory Medicine, Clinical Microbiology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-4888-6771
Tobias M HohlDepartment of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Robert A CramerGeisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, New Hampshire, USA.
Joshua J ObarGeisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, New Hampshire, USA joshua.j.obar@dartmouth.edu.ORCID 0000-0003-4068-7911
Dartmouth College · USMemorial Sloan Kettering Cancer Center · USMiami University · USMontana State University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Molecular and Cellular Biology at DartmouthT32GM008704 · NIGMS · DARTMOUTH COLLEGE · PI COMPTON, DUANE A. · 1998 to 2018
$6.8M
TRANSLATIONAL RESEARCH COREP30GM106394 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2013 to 2017
$6.1M
University of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR01AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HOHL, TOBIAS M · 2011 to 2020
$4.9M
Center for Molecular, Cellular, and Translational ImmunologyP30GM103415 · NIGMS · DARTMOUTH COLLEGE · PI GREEN, WILLIAM R · 2012 to 2015
$4.7M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR37AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TOBIAS M HOHL · 2021 to 2026
$4.2M
Hypoxia Adaptation and Fungal Virulence of Aspergillus fumigatusR01AI081838 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI CRAMER, ROBERT ANDREW · 2009 to 2017
$2.9M
Dissection of Macrophage Antifungal Activity against Aspergillus fumigatusR21AI105617 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HOHL, TOBIAS M · 2013 to 2014
$473k
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI081838NIAID NIH HHS R01 AI093808NIAID NIH HHS R21 AI105617NIAID NIH HHS R37 AI093808NIGMS NIH HHS P30 GM103415NIGMS NIH HHS P30 GM106394NIGMS NIH HHS R25 GM086262NIGMS NIH HHS T32 GM008704
6 · The paper itself

Abstract

Heterogeneity among

Indexed as

AnimalsAspergillosisAspergillus fumigatusCells, CulturedImmunocompetenceInflammationInterleukin-1alphaLungMacrophagesMiceMice, Inbred C57BLMice, KnockoutPhenotypeSpores, FungalVirulenceInterleukin-1alphaaspergillosisAspergillus fumigatusIL-1innate immunityinvasive fungal infectionlung defenselung infectionmucosal immunityneutrophilsrespiratory pathogens

Identifiers

PMID28947643
PMCPMC5695118
OpenAlexW2759554126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.