Evidence map›Paper›PMID 28947565›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

NY-ESO-1 Vaccination in Combination with Decitabine Induces Antigen-Specific T-lymphocyte Responses in Patients with Myelodysplastic Syndrome.

Elizabeth A Griffiths, Pragya Srivastava, Junko Matsuzaki, Zachary Brumberger, Eunice S Wang, Justin Kocent, Austin Miller, Gregory W Roloff, Hong Yuen Wong, Benjamin E Paluch and 6 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03941496 (Phase 1b/2a Safety and Immunogenicity of the DNMT Inhibitor Azacitidine During Anti-Tuberculosis Therapy), which is not on this map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03941496 phase1 / phase2withdrawnnot on this mapstarted 2022, after this paper: background citation

Phase 1b/2a Safety and Immunogenicity of the DNMT Inhibitor Azacitidine During Anti-Tuberculosis Therapy

TypeinterventionalSponsorAndrew DinardoRan2022 to 2023Enrolled0ConditionsTuberculosis, PulmonaryArmsAzacitidine Injection
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
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  16. Vaccines: a promising therapy for myelodysplastic syndrome.Journal of hematology & oncology · 2024
    Review
  17. Review
  18. Article
  19. Review
  20. Recombinant antigen delivery to dendritic cells as a way to improve vaccine design.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Elizabeth A GriffithsDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, New York. elizabeth.griffiths@roswellpark.org michael.nemeth@roswellpark.org.
Pragya SrivastavaDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
Junko MatsuzakiCenter for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York.
Zachary BrumbergerDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
Eunice S WangDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
Justin KocentClinical Research Services, Roswell Park Cancer Institute, Buffalo, New York.
Austin MillerDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York.
Gregory W RoloffMyeloid Malignancies Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Hong Yuen WongMyeloid Malignancies Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Benjamin E PaluchDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York.
Linda G Lutgen-DunckleyDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
Brandon L MartensDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
Kunle OdunsiDepartment of Immunology, Roswell Park Cancer Institute, Buffalo, New York.
Adam R KarpfEppley Institute for Cancer Research, The Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska.
Christopher S HouriganMyeloid Malignancies Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Michael J NemethDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, New York. elizabeth.griffiths@roswellpark.org michael.nemeth@roswellpark.org.
Roswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Detection, prevention and treatment of acute myeloid leukemia (AML) relapse.ZIAHL006163 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI HOURIGAN, CHRISTOPHER · 2013 to 2023
$21.0M
RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B. · 2013 to 2025
$19.6M
DRUG DEVELOPMENT AND CANCER TREATMENTST32CA009072 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI JOHNSON, CANDACE S · 1985 to 2014
$2.3M
Intramural NIH HHS ZIA HL006163NCI NIH HHS P30 CA016056NCI NIH HHS P50 CA159981NCI NIH HHS T32 CA009072
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAntigens, NeoplasmAntimetabolites, AntineoplasticCancer VaccinesCarboxymethylcellulose SodiumCombined Modality TherapyDecitabineDose-Response Relationship, DrugDrug Administration ScheduleFeasibility StudiesHumansImmunotherapyInterferon InducersLeukemia, Myeloid, AcuteMembrane ProteinsMiddle AgedAntigens, NeoplasmAntimetabolites, AntineoplasticCancer VaccinesCarboxymethylcellulose SodiumCTAG1B protein, humanDecitabineInterferon InducersMembrane ProteinsPoly I-Cpoly ICLCPolylysine

Identifiers

PMID28947565
PMCPMC5844797
OpenAlexW2758263899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.