ArticleDevelopment (Cambridge, England)2017
Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification.
Open access · greenAbstract read
In one paragraph
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Current strategies and opportunities to manufacture cells for modeling human lungs.Advanced drug delivery reviews · 2020Pooled it
- Foxe1 deficiency impairs thyroid fate while supporting lung differentiation.EMBO reports · 2026Article
- Human thyroid organoids: tools for understanding thyroid diseases and development.Nature reviews. Endocrinology · 2026Review
- Long isoforms of the COPD risk gene FAM13A orchestrate human lung epithelial development.American journal of respiratory cell and molecular biology · 2026Article
- Endocrinology at a Miniature Level: Pluripotent Stem-Cell-Derived Organoid Models of Hypothalamus-Pituitary Axes.Biomolecules · 2026Review
- Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Stage-specific signaling modulation generates low-tumorigenicity thyroid progenitors from human pluripotent stem cells.Frontiers in endocrinology · 2026Article
- Microfluidic lung cancer models: Bridging clinical treatment strategies and tumor microenvironment recapitulation.APL bioengineering · 2025Review
- An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification.Nature communications · 2025Article
- Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells.Nature protocols · 2025Review
- Recent Advancements in the Generation and Application of Therapeutic Cell Populations for Lung Epithelial Repair.Journal of tissue engineering and regenerative medicine · 2025Review
- Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells.Stem cell reports · 2024Article
- Building a human lung from pluripotent stem cells to model respiratory viral infections.Respiratory research · 2024Review
- Lung repair and regeneration: Advanced models and insights into human disease.Cell stem cell · 2024Review
- Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids.Oncogene · 2024Article
- Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration.Nature communications · 2023Article
- Recent advances in lung organoid development and applications in disease modeling.The Journal of clinical investigation · 2023Review
- Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells.Cell stem cell · 2023Article
- Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice.Cell stem cell · 2023Article
- Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Maria SerraCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.ORCID 0000-0002-9885-8093
Konstantinos-Dionysios AlysandratosCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Finn HawkinsCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Katherine B McCauleyCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Anjali JacobCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Jinyoung ChoiDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA.
Ignacio S CaballeroCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Marall VedaieCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Anita A KurmannDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA.
Laertis IkonomouCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Anthony N HollenbergDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA.
John M ShannonDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA john.shannon@cchmc.org dkotton@bu.edu.
Darrell N KottonCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA john.shannon@cchmc.org dkotton@bu.edu.ORCID 0000-0002-9604-8476
Boston University · USBeth Israel Deaconess Medical Center · USCincinnati Children's Hospital Medical Center · US
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MEditing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3MDerivation of Transplantable Lung Epithelial Progenitors from iPS CellsR01HL095993 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2009 to 2026
$7.5M"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9MThyroid Follicular Cell Signaling and Development in HumansR01DK105029 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANTHONY N HOLLENBERG, Darrell N. Kotton · 2016 to 2026
$3.7MBioengineering of Transplantable Humanized Lungs from iPS CellsR01HL108678 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N., VACANTI, JOSEPH P · 2011 to 2014
$2.8MEpigenenomic and transcriptomic networks in normal and defective lung developmentR01HL128172 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2015 to 2018
$2.2MDefining the genetic program of primordial lung progenitorsR01HL111574 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI IKONOMOU, LAERTIS · 2012 to 2016
$2.1MLPCAT1 is essential for perinatal lung function and survivalR01HL098319 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SHANNON, JOHN M · 2010 to 2013
$1.9MiPSC Modeling of the Role of NKX2-1 in Human Lung Development and DiseaseR01HL122442 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2014 to 2017
$1.6MBiomechanical determinants of lung cell fate in pluripotent stem cellsR01HL124280 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI IKONOMOU, LAERTIS, WONG, JOYCE Y · 2014 to 2017
$1.6MNCATS NIH HHS UL1 TR001430NHLBI NIH HHS R01 HL095993NHLBI NIH HHS R01 HL098319NHLBI NIH HHS R01 HL108678NHLBI NIH HHS R01 HL111574NHLBI NIH HHS R01 HL122442NHLBI NIH HHS R01 HL128172NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01 HL134745NIDDK NIH HHS R01 DK105029
Abstract
The
Indexed as
Body PatterningCell DifferentiationSignal TransductionAnimalsBiomarkersBone Morphogenetic ProteinsCell LineageEmbryo, MammalianEmbryonic DevelopmentEndodermEpithelial CellsFibroblast Growth FactorsGene Expression ProfilingGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHomeodomain ProteinsBiomarkersBone Morphogenetic ProteinsFibroblast Growth FactorsGreen Fluorescent ProteinsHomeodomain ProteinsWnt ProteinsEmbryoEndodermLungNkx2-1Pluripotent stem cellsThyroid
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.