Trial reportAntimicrobial agents and chemotherapy2017
Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.
Philippine Eloy, Adrien Tessier, Patty Fan-Havard, Monidarin Chou, Céline Verstuyft, Anne-Marie Taburet, David W Haas, Julie Bertrand, ANRS12154 Study Group
Open access · bronzeAbstract readClinical Trial
In one paragraphTrial report in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors at 7 institutions in 3 countries.
Philippine EloyUniversité Paris Diderot, Sorbonne Paris Cité, Paris, France.
Adrien TessierDivision of Clinical Pharmacokinetics and Pharmacometrics, Institut de Recherches Internationales Servier, Suresnes, France.
Patty Fan-HavardSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Amherst, New York, USA.
Monidarin ChouRodolphe Mérieux Laboratory, Faculty of Pharmacy, University of Health Sciences, Phnom Penh, Cambodia.
Céline VerstuyftFaculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Anne-Marie TaburetINSERM U1184, Le Kremlin-Bicêtre, France.
David W HaasVanderbilt University School of Medicine, Departments of Medicine, Pharmacology, Pathology, and Microbiology and Immunology, Nashville, Tennessee, USA.
Julie BertrandUniversité Paris Diderot, Sorbonne Paris Cité, Paris, France julie.bertrand@inserm.fr.ORCID 0000-0002-6568-1041 ANRS12154 Study Group
Délégation Paris 7 · FRInserm · FRMeharry Medical College · USServier (France) · FRThe Ohio State University · USUniversité Paris-Sud · FRUniversity of Health Science · KH
Funding
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MTennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Stephany Norah Duda · 2015 to 2026
$27.5MPharmacogenomics of HIV TherapyR01AI077505 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAAS, DAVID W · 2008 to 2025
$12.3MMedical Research Council MR/J014338/1NCATS NIH HHS UL1 TR000445NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI077505
6 · The paper itselfAbstract
Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites: 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations between
Indexed as
NevirapineAdultAnti-HIV AgentsAsian PeopleCambodiaCytochrome P-450 CYP2B6FemaleHIV InfectionsHumansMalePolymorphism, Single NucleotideAnti-HIV AgentsCYP2B6 protein, humanCytochrome P-450 CYP2B6Nevirapinegenetic polymorphismsmetabolism pathwaysnevirapinepopulation pharmacokinetics
Identifiers
PMID28947469
PMCPMC5700353
OpenAlexW2756991385
What OpenQuestion holds
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