Evidence map›Paper›PMID 28947466›Full record

Trial reportBMJ open2017

Randomised controlled trial of

David Schnadower, Phillip I Tarr, T Charles Casper, Marc H Gorelick, Michael J Dean, Karen J O'Connell, Prashant Mahajan, Thomas H Chun, Seema R Bhatt, Cindy G Roskind and 6 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01773967 (Impact of Emergency Department Probiotic), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01773967 phase2 / phase3completednot on this map

Impact of Emergency Department Probiotic (LGG) Treatment of Pediatric Gastroenteritis

TypeinterventionalSponsorWashington University School of MedicineRan2014 to 2018Enrolled971ConditionsGastroenteritisArmsLGG, micro-crystalline cellulose
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Pathogen-Specific Effects of Probiotics in Children With Acute Gastroenteritis Seeking Emergency Care: A Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Effects of therapeutic probiotics on modulation of microRNAs.Cell communication and signaling : CCS · 2021
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 2 countries.

David SchnadowerDivision of Pediatric Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Phillip I TarrDivision of Gastroenterology and Nutrition, Department of Pediatrics, Washington University, School of Medicine, St. Louis, Missouri, USA.
T Charles CasperDepartment of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
Marc H GorelickCentral Administration, Children's Hospital Minnesota, Minneapolis, Minnesota, USA.
Michael J DeanDepartment of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
Karen J O'ConnellDivision of Emergency Medicine, Children's National Health System, Department of Pediatrics, The George Washington School of Medicine and Health Sciences, Washington, DC, USA.
Prashant MahajanDivision of Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan Wayne State University, Detroit, Michigan, USA.
Thomas H ChunDepartment of Emergency Medicine and Pediatrics Providence, Hasbro Children's Hospital and Brown University, Providence, Rhode Island, USA.
Seema R BhattDivision of Emergency Medicine, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Cindy G RoskindDivision of Emergency Medicine, Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, New York, USA.
Elizabeth C PowellDivision of Emergency Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Alexander J RogersDepartments of Emergency Medicine and Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Cheryl VanceDepartments of Emergency Medicine and Pediatrics, University of California, Davis, School of Medicine, Sacramento, California, USA.
Robert E SapienDepartment of Emergency Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Feng GaoDepartment of Surgery, Division of Public Health Sciences, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Stephen B FreedmanSections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Washington University in St. Louis · USUniversity of Michigan–Ann Arbor · USUniversity of Utah · USBrown University · USChildren's National · USColumbia University · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityUniversity of Calgary · CAUniversity of California, Davis · USUniversity of Cincinnati · USUniversity of Minnesota Children's Hospital · USUniversity of New Mexico · US

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Impact of Emergency Department Probiotic Treatment of Pediatric GastroenteritisR01HD071915 · NICHD · WASHINGTON UNIVERSITY · PI FREEDMAN, STEPHEN BRADLEY, SCHNADOWER, DAVID · 2014 to 2018
$3.6M
NICHD NIH HHS R01 HD071915NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

introductionAcute gastroenteritis (AGE) is a common and burdensome condition that affects millions of children worldwide each year. Currently available strategies are limited to symptomatic management, treatment and prevention of dehydration and infection control; no disease-modifying interventions exist. Probiotics, defined as live microorganisms beneficial to the host, have shown promise in improving AGE outcomes, but existing studies have sufficient limitations such that the use of probiotics cannot currently be recommended with confidence. Here we present the methods of a large, rigorous, randomised, double-blind placebo-controlled study to assess the effectiveness and side effect profile of METHODS AND ANALYSIS: The study is being conducted in 10 US paediatric emergency departments (EDs) within the federally funded Pediatric Emergency Care Applied Research Network, in accordance with current SPIRIT and CONSORT statement recommendations. We will randomise 970 children presenting to participating EDs with AGE to either 5 days of treatment with LGG (10 ETHICS AND DISSEMINATION: Institutional review board approval has been obtained at all sites, and data and material use agreements have been established between the participating sites. The results of the trial will be published in peer-reviewed journals. A deidentified public data set will be made available after the completion of all study procedures. TRIAL REGISTRATION NUMBER: NCT01773967.

Indexed as

Lacticaseibacillus rhamnosusAcute DiseaseChildChild, PreschoolClinical ProtocolsDouble-Blind MethodEmergency Service, HospitalFemaleGastroenteritisHumansInfantIntention to Treat AnalysisMaleProbioticsSeverity of Illness IndexPaediatric Gastroenterology

Identifiers

PMID28947466
PMCPMC5623493
OpenAlexW2757686485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.