Evidence map›Paper›PMID 28947377›Full record

ReviewNeuropharmacology2018

Injury mechanisms in acute intracerebral hemorrhage.

D Andrew Wilkinson, Aditya S Pandey, B Gregory Thompson, Richard F Keep, Ya Hua, Guohua Xi

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06816641 (Surgical Evacuation Of Spontaneous Intracerebral Hematoma), which is not on this map. Cited by 155 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 8 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06816641 narecruitingnot on this mapstarted 2022, after this paper: background citation

Surgical Evacuation Of Spontaneous Intracerebral Hematoma: Clinical Outcomes and Prognostic Factors

TypeinterventionalSponsorSohag UniversityRan2022 to 2025Enrolled40ConditionsIntracerebral Haemorrhage (ICH)ArmsSurgical Evacuation of Intracerebral Hemorrhage
3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 8 syntheses or guidelines pooled it, 255 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  15. HumanBioactive materials · 2026
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

D Andrew WilkinsonDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: dawilki@umich.edu.
Aditya S PandeyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
B Gregory ThompsonDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: guohuaxi@umich.edu.
University of Michigan · US

Funding

TRAINING IN CLINICAL AND BASIC NEUROSCIENCET32NS007222 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 1985 to 2026
$8.0M
Iron, minocycline and brain injury after intracerebral hemorrhageR01NS090925 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2015 to 2019
$1.7M
Targeting CD47 to aid in clearing intracerebral hemorrhagesR01NS096917 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA, XI, GUOHUA · 2016 to 2020
$1.7M
Mechanisms of Brain Injury after Intraventricular HemorrhageR01NS073595 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2012 to 2016
$1.7M
Mechanisms of early brain injury after subarachnoid hemmorrhageR01NS079157 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2012 to 2016
$1.7M
Lipocalin-2 and Intracerebral Hemorrhage-induced Brain InjuryR21NS091545 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2015 to 2016
$427k
Perivascular astrocyte swelling after BBB disruptionR21NS093399 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2015 to 2016
$426k
NINDS NIH HHS R01 NS073595NINDS NIH HHS R01 NS079157NINDS NIH HHS R01 NS090925NINDS NIH HHS R01 NS096917NINDS NIH HHS R21 NS091545NINDS NIH HHS R21 NS093399NINDS NIH HHS T32 NS007222
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled 'Cerebral Ischemia'.

Indexed as

AnimalsBrainBrain EdemaCerebral HemorrhageHumansSignal TransductionBrain edemaHematomaHypertensionIntracerebral hemorrhageIronThrombin

Identifiers

PMID28947377
PMCPMC6027647
OpenAlexW2757856543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.