Evidence map›Paper›PMID 28947107›Full record

ReviewSeminars in immunology2017

Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells.

Haifa Shen, Tong Sun, Hanh H Hoang, Jana S Burchfield, Gillian F Hamilton, Elizabeth A Mittendorf, Mauro Ferrari

Abstract readReview
In one paragraph

Review in Seminars in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  13. Nanotechnology and Immunotherapy in Ovarian Cancer: Tracing New Landscapes.The Journal of pharmacology and experimental therapeutics · 2019
    Review
  14. Article
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  18. Folate-Functionalized Mesoporous Hollow SnOBioMed research international · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Haifa ShenHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA.
Tong SunHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA.
Hanh H HoangHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA.
Jana S BurchfieldHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA.
Gillian F HamiltonHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA.
Elizabeth A MittendorfDepartment of Breast Surgical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mauro FerrariHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: mferrari@HoustonMethodist.org.
Houston Methodist · US

Funding

Transport Oncophysics CoreU54CA210181 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WANG, RONGFU · 2016 to 2020
$9.3M
Tumor vasculature-targeted nanotherapeutics for DNA damage responseR01CA193880 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI SHEN, HAIFA · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA193880NCI NIH HHS U54 CA210181
6 · The paper itself

Abstract

Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes - collectively referred to as transport barriers - including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.

Indexed as

NanotechnologyAnimalsAntigen PresentationCell MovementDendritic CellsHumansImmunotherapyLymphocyte ActivationNanoparticlesNeoplasmsT-LymphocytesTumor MicroenvironmentCancer immunotherapyNanotechnologyTumor-infiltrating lymphocytesTumor microenvironment

Identifiers

PMID28947107
PMCPMC5705528
OpenAlexW2760359081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.