Evidence map›Paper›PMID 28946858›Full record

ArticleBMC public health2017

Comparative analysis of package inserts of local and imported antihypertensive medications in Palestine.

Sandra A Qatmosh, Amer A Koni, Baraa G Qeeno, Dina A Arandy, Maysa W Abu-Hashia, Bahaa M Al-Hroub, Sa'ed H Zyoud

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Evaluation of Medication Package Inserts in Ethiopia.Journal of environmental and public health · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Evaluation of Medication Package Inserts in Iran.Journal of research in pharmacy practice
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sandra A QatmoshPharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Amer A KoniPharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Baraa G QeenoPharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Dina A ArandyPharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Maysa W Abu-HashiaPharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Bahaa M Al-HroubPharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Sa'ed H ZyoudPoison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine. saedzyoud@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPackage inserts (PIs) as a reliable reference for patients and health care providers should provide accurate, complete and up-to-date information. The purpose of the current study is to assess and compare the PIs of antihypertensive agents locally produced in Palestine and their imported counterparts.

methodsThirty-five PIs were assessed for the presence of 31 information statements using a scoring method. Word counting of 20 headings and subheadings was used to evaluate and compare local and imported PIs for information quantity.

resultsNone of the analysed PIs fulfilled the criteria. All of them included the brand name, active ingredients, indications, directions for use, adverse drug reactions, drug-drug interactions, pregnancy and lactation considerations, and storage. Whereas none of them, either local or imported PIs, included the shelf life and instructions to convert tablets or capsules into liquid forms. Additionally, only one (5%) imported and no (0%) local PIs mentioned the duration of therapy. Moreover, 93.4% of local PIs were deficient in areas regarding the inactive ingredients and date of last revision, and 86.7% did not mention the drug dose and possibility of tablet splitting. Furthermore, the maximum dose was not indicated in 90% of imported and 86.7% of local PIs. In general, imported PIs contained more detailed information than their local counterparts, where the range of differences in medians between the local and imported PIs was from 1.5-fold for pregnancy considerations to >42.00-fold for the effect on the ability to drive and use machines.

conclusionsThe findings of this study revealed the superiority of imported over local PIs in both quality and quantity of information provided. This emphasises the need for appropriate measures to be taken by the Ministry of Health and local manufacturers to ensure efficiency of local PIs in providing accurate, complete and up-to-date information.

Indexed as

Antihypertensive AgentsCommerceDrug LabelingHumansIsraelAntihypertensive AgentsAntihypertensive medicationsPackage insertsPalestine

Identifiers

PMID28946858
PMCPMC5613627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.