Evidence map›Paper›PMID 28946832›Full record

Trial reportInternational journal of stroke : official journal of the International Stroke Society2017

A multicenter randomized controlled trial of endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3).

Gregory W Albers, Maarten G Lansberg, Stephanie Kemp, Jenny P Tsai, Phil Lavori, Soren Christensen, Michael Mlynash, Sun Kim, Scott Hamilton, Sharon D Yeatts and 4 more

2 registry-linked trialsAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of stroke : official journal of the International Stroke Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 152 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02586415 naterminatednot on this map

Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3

TypeinterventionalSponsorGregory W AlbersRan2016 to 2017Enrolled182ConditionsStroke, Acute, Cerebral InfarctionArmsEndovascular Thrombectomy, Trevo Retriever, Solitaire™ FR Revascularization Device, Penumbra thrombectomy system, Covidien MindFrame Capture Revascularization Device
NCT06148675 completednot on this mapstarted 2023, after this paper: background citation

MINT Registry : Macrowire for IntracraNial Thrombectomy

TypeobservationalSponsorIndiana UniversityRan2023 to 2025Enrolled105ConditionsStroke, Acute IschemicArmsNo Intervention
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Guideline
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  8. Pooled it
  9. Trial
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  11. Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Trial
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  17. Role of mechanical thrombectomy in pediatric acute ischemic stroke: a case series.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  18. Article
  19. Article
  20. Intracranial stenting for large vessel intracranial atherosclerotic disease: Retrospective study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gregory W Albers1 Stanford University, Stanford, CA, USA.
Maarten G Lansberg1 Stanford University, Stanford, CA, USA.
Stephanie Kemp1 Stanford University, Stanford, CA, USA.
Jenny P Tsai1 Stanford University, Stanford, CA, USA.
Phil Lavori1 Stanford University, Stanford, CA, USA.
Soren Christensen1 Stanford University, Stanford, CA, USA.
Michael Mlynash1 Stanford University, Stanford, CA, USA.
Sun Kim1 Stanford University, Stanford, CA, USA.
Scott Hamilton1 Stanford University, Stanford, CA, USA.
Sharon D Yeatts2 Medical University of South Carolina, Charleston, SC, USA.
Yuko Palesch2 Medical University of South Carolina, Charleston, SC, USA.
Roland Bammer1 Stanford University, Stanford, CA, USA.
Joe Broderick3 University of Cincinnati, Cincinnati, OH, USA.
Michael P Marks1 Stanford University, Stanford, CA, USA.

Funding

DEFUSE 3: EnDovascular ThErapy Following Imaging EvalUation for ISchemic StrokE 3U01NS092076 · NINDS · STANFORD UNIVERSITY · PI ALBERS, GREGORY W · 2015 to 2016
$5.3M
Stanford University Regional Coordinating Stroke Center for the NIH Stroke Trials NetworkU24NS107220 · NINDS · STANFORD UNIVERSITY · PI MAARTEN G LANSBERG · 2018 to 2026
$2.8M
Stanford University Regional Coordinating Stroke Center for the NINDS Stroke TriaU10NS086487 · NINDS · STANFORD UNIVERSITY · PI ALBERS, GREGORY W · 2013 to 2017
$1.9M
NINDS NIH HHS U01 NS092076NINDS NIH HHS U10 NS086487NINDS NIH HHS U24 NS107220
6 · The paper itself

Abstract

Rationale Early reperfusion in patients experiencing acute ischemic stroke is effective in patients with large vessel occlusion. No randomized data are available regarding the safety and efficacy of endovascular therapy beyond 6 h from symptom onset. Aim The aim of the study is to demonstrate that, among patients with large vessel anterior circulation occlusion who have a favorable imaging profile on computed tomography perfusion or magnetic resonance imaging, endovascular therapy with a Food and Drug Administration 510 K-cleared mechanical thrombectomy device reduces the degree of disability three months post stroke. Design The study is a prospective, randomized, multicenter, phase III, adaptive, blinded endpoint, controlled trial. A maximum of 476 patients will be randomized and treated between 6 and 16 h of symptom onset. Procedures Patients undergo imaging with computed tomography perfusion or magnetic resonance diffusion/perfusion, and automated software (RAPID) determines if the Target Mismatch Profile is present. Patients who meet both clinical and imaging selection criteria are randomized 1:1 to endovascular therapy plus medical management or medical management alone. The individual endovascular therapist chooses the specific device (or devices) employed. Study outcomes The primary endpoint is the distribution of scores on the modified Rankin Scale at day 90. The secondary endpoint is the proportion of patients with modified Rankin Scale 0-2 at day 90 (indicating functional independence). Analysis Statistical analysis for the primary endpoint will be conducted using a normal approximation of the Wilcoxon-Mann-Whitney test (the generalized likelihood ratio test).

Indexed as

Endovascular ProceduresAdolescentAdultAgedAged, 80 and overBrain IschemiaDisability EvaluationHumansMagnetic Resonance ImagingMechanical ThrombolysisMiddle AgedPattern Recognition, AutomatedPerfusion ImagingSoftwareStrokeTomography, X-Ray ComputedAcute ischemic strokebrain imagingclinical trialendovascularimaging based selectionrecanalization

Identifiers

PMID28946832
PMCPMC5916787

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.