ArticleThe American journal of psychiatry2017
Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample.
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Article in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
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69citing papers in PubMed, 5 pooled it
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Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Mind the brain gap: The worldwide distribution of neuroimaging research on adolescent depression.NeuroImage · 2021Pooled it
- Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies.The American journal of psychiatry · 2018Pooled it
- Consummatory deficits in close social reward predict inflammation-induced depressed mood.Psychoneuroendocrinology · 2026Trial
- Multilevel growth curve analyses of behavioral activation for anhedonia (BATA) and mindfulness-based cognitive therapy effects on anhedonia and resting-state functional connectivity: Interim results of a randomized trialJournal of affective disorders · 2021Trial
- Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals.Molecular psychiatry · 2021Trial
- Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone.Psychological medicine · 2019Trial
- Altered reward-related resting-state network properties in adolescent cannabis use and depression.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Temporal dynamic changes in functional connectivity of reward network in depressed adolescents and young adults with and without suicidal attempts.BMC psychiatry · 2025Article
- Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth.Neuroimage. Reports · 2025Article
- Divergent Longitudinal Trajectories and Neurotransmitter Associations of Striatal Subparcellation Spontaneous Activity in Major Depressive Disorder.Biological psychiatry global open science · 2025Article
- Frontostriatal Networks Undergo Functional Specialization during Adolescence That Follows a Ventral-Dorsal Gradient: Developmental Trajectories and Longitudinal Associations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dopamine D1 receptor agonist alleviates post-weaning isolation-induced neuroinflammation and depression-like behaviors in female mice.Behavioral and brain functions : BBF · 2025Article
- Predicting the onset of internalizing disorders in early adolescence using deep learning optimized with AI.Frontiers in psychiatry · 2025Article
- Ventral striatal-cingulate resting-state functional connectivity in healthy adolescents relates to later depression symptoms in adulthood.Journal of affective disorders · 2024Article
- Functional Abnormality of the Reward System in Depressed Adolescents and Young Adults with and without Suicidal Behavior.Brain topography · 2024Article
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Pedro Mario PanFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
João R SatoFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Giovanni A SalumFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Luis A RohdeFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Ary GadelhaFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Andre ZugmanFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Jair MariFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Andrea JackowskiFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Felipe PiconFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Eurípedes C MiguelFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Daniel S PineFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Ellen LeibenluftFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Rodrigo A BressanFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Argyris StringarisFrom the Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil; the Mood, Brain, and Development Unit, Emotion and Development Branch, NIMH, Bethesda, Md.; Center for Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil; the Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; the Department and Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Section on Development and Affective Neuroscience and the Section on Mood Dysregulation and Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md.; the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Funding
Mood, Brain, and Development UnitZIAMH002957 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI STRINGARIS, ARGYRIOS · 2017 to 2022
$14.8MfMRI Study Of Risk Of Mood/Anxiety Disorders In ChildrenZ01MH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.7MFmri Studies Of Pediatric Mood And Anxiety DisordersZ01MH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.5MFmri Studies Of Emotional DevelopmentZ01MH002780 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.4MIntramural NIH HHS Z01 MH002781Intramural NIH HHS Z01 MH002782Wellcome Trust
Abstract
objectivePrevious studies have implicated aberrant reward processing in the pathogenesis of adolescent depression. However, no study has used functional connectivity within a distributed reward network, assessed using resting-state functional MRI (fMRI), to predict the onset of depression in adolescents. This study used reward network-based functional connectivity at baseline to predict depressive disorder at follow-up in a community sample of adolescents.
methodA total of 637 children 6-12 years old underwent resting-state fMRI. Discovery and replication analyses tested intrinsic functional connectivity (iFC) among nodes of a putative reward network. Logistic regression tested whether striatal node strength, a measure of reward-related iFC, predicted onset of a depressive disorder at 3-year follow-up. Further analyses investigated the specificity of this prediction.
resultsIncreased left ventral striatum node strength predicted increased risk for future depressive disorder (odds ratio=1.54, 95% CI=1.09-2.18), even after excluding participants who had depressive disorders at baseline (odds ratio=1.52, 95% CI=1.05-2.20). Among 11 reward-network nodes, only the left ventral striatum significantly predicted depression. Striatal node strength did not predict other common adolescent psychopathology, such as anxiety, attention deficit hyperactivity disorder, and substance use.
conclusionsAberrant ventral striatum functional connectivity specifically predicts future risk for depressive disorder. This finding further emphasizes the need to understand how brain reward networks contribute to youth depression.
Indexed as
AdolescentBrainBrazilChildCohort StudiesDepressive DisorderFemaleFollow-Up StudiesFunctional NeuroimagingHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMajor Depressive DisorderMaleOdds RatioAdolescentsBrain Imaging TechniquesCohortDepressionMood Disorders-UnipolarReward
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