ArticleSensors (Basel, Switzerland)2017
A Multi-Fluorescent DNA/Graphene Oxide Conjugate Sensor for Signature-Based Protein Discrimination.
Article in Sensors (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Development of Optical Differential Sensing Based on Nanomaterials for Biological Analysis.Biosensors · 2024Review
- Graphene Oxide/Nitrocellulose Non-Covalent Hybrid as Solid Phase for Oligo-DNA Extraction from Complex Medium.Molecules (Basel, Switzerland) · 2023Article
- Rapid Fluorescence Sensor Guided Detection of Urinary Tract Bacterial Infections.International journal of nanomedicine · 2022Article
- Graphdiyne nanosheets as a platform for accurate copper(ii) ion detectionRSC advances · 2021Article
- Functionalized Graphene Platforms for Anticancer Drug Delivery.International journal of nanomedicine · 2021Review
- A Multichannel Pattern-Recognition-Based Protein Sensor with a Fluorophore-Conjugated Single-Stranded DNA Set.Sensors (Basel, Switzerland) · 2020Article
- Pattern-recognition-based Sensor Arrays for Cell Characterization: From Materials and Data Analyses to Biomedical Applications.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Review
- Composite-Scattering Plasmonic Nanoprobes for Label-Free, Quantitative Biomolecular Sensing.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors.RSC advances · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Signature-based protein sensing has recently emerged as a promising prospective alternative to conventional lock-and-key methods. However, most of the current examples require the measurement of optical signals from spatially-separated materials for the generation of signatures. Herein, we present a new approach for the construction of multi-fluorescent sensing systems with high accessibility and tunability, which allows generating protein fluorescent signatures from a single microplate well. This approach is based on conjugates between nano-graphene oxide (nGO) and three single-stranded DNAs (ssDNAs) that exhibit different sequences and fluorophores. Initially, the three fluorophore-modified ssDNAs were quenched simultaneously by binding to nGO. Subsequent addition of analyte proteins caused a partial recovery in fluorescent intensity of the individual ssDNAs. Based on this scheme, we have succeeded in acquiring fluorescence signatures unique to (i) ten proteins that differ with respect to pI and molecular weight and (ii) biochemical marker proteins in the presence of interferent human serum. Pattern-recognition methods demonstrated high levels of discrimination for this system. The high discriminatory power and simple format of this sensor system should enable an easy and fast evaluation of proteins and protein mixtures.
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