ArticleNutrients2017
Coptidis Rhizoma Prevents Heat Stress-Induced Brain Damage and Cognitive Impairment in Mice.
Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Mesenchymal stem cell-derived extracellular vesicles ameliorate heat stroke-induced hippocampal injury and modulate VIM-AS1-associated miR-34a-5p/Per2 signaling.Frontiers in immunology · 2026Article
- Heatstroke-Induced Inflammatory Response and Therapeutic Biomarkers.Biomedicines · 2025Review
- A haplotype-resolved genome assembly of Coptis teeta, an endangered plant of significant medicinal value.Scientific data · 2024Article
- Genetic patterning in hippocampus of rat undergoing impaired spatial memory induced by long-term heat stress.Heliyon · 2024Article
- Article
- Insulin-like growth factor 1 in heat stress-induced neuroinflammation: novel perspective about the neuroprotective role of chromium.Stress biology · 2023Review
- Effect of Heat Stress on Hippocampal Neurogenesis: Insights into the Cellular and Molecular Basis of Neuroinflammation-Induced Deficits.Cellular and molecular neurobiology · 2023Review
- Therapeutic potential of traditional Chinese medicine on heat stroke.Frontiers in pharmacology · 2023Review
- β-Hydroxybutyric acid improves cognitive function in a model of heat stress by promoting adult hippocampal neurogenesis.Stress biology · 2022Article
- Antioxidative and anti-inflammatory effects of vitamin C on the liver of laying hens under chronic heat stress.Frontiers in veterinary science · 2022Article
- Editorial: Relieving stress response in animals.Frontiers in veterinary science · 2022Article
- Nutritional supplements formulated to prevent cognitive impairment in animals.Current research in food science · 2022Article
- Sericin Alleviates Thermal Stress Induced Anxiety-Like Behavior and Cognitive Impairment Through Regulation of Oxidative Stress, Apoptosis, and Heat-Shock Protein-70 in the Hippocampus.Neurochemical research · 2021Article
- Heat Stress Alters the Intestinal Microbiota and Metabolomic Profiles in Mice.Frontiers in microbiology · 2021Article
- Bioinformatics analysis of endophytic bacteria related to berberine in the Chinese medicinal plant3 Biotech · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress conditions lead to neuroinflammation, neuronal death, and memory loss in animals. Coptidis Rhizoma (CR) exhibits potent fever-reducing effects and has been used as an important traditional medicinal herb for treating fever. However, to date, the effects of antipyretic CR on heat-induced brain damages have not been investigated. In this study, CR significantly reduced the elevation of ear and rectal temperatures after exposure to heat in mice. Additionally, CR attenuated hyperthermia-induced stress responses, such as release of cortisol into the blood, and upregulation of heat shock protein and c-Fos in the hypothalamus and hippocampus of mice. The administration of CR inhibited gliosis and neuronal loss induced by thermal stress in the hippocampal CA3 region. Treatment with CR also reduced the heat stress-induced expression of nuclear factor kappa β, tumor necrosis factor-α, and interleukin-1β (IL-1β) in the hippocampus. Moreover, CR significantly decreased proinflammatory mediators such as IL-9 and IL-13 in the heat-stressed hypothalamus. Furthermore, CR attenuated cognitive dysfunction triggered by thermal stress. These results indicate that CR protects the brain against heat stress-mediated brain damage via amelioration of hyperthermia and neuroinflammation in mice, suggesting that fever-reducing CR can attenuate thermal stress-induced neuropathology.
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Registered trials
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