Evidence map›Paper›PMID 28946562›Full record

ArticleCancer biomarkers : section A of Disease markers2017

Midkine and pleiotrophin concentrations in needle biopsies of breast and lung masses.

Nicole M Giamanco, Youn Hee Jee, Anton Wellstein, Craig D Shriver, Thomas A Summers, Jeffrey Baron

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Pleiotrophin drives a prometastatic immune niche in breast cancer.The Journal of experimental medicine · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Nicole M GiamancoDepartment of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Youn Hee JeeEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Anton WellsteinLombardi Comprehensive Cancer Center, Georgetown University, Washington D.C., USA.
Craig D ShriverJohn P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Thomas A SummersDepartment of Pathology and Laboratory Services, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Jeffrey BaronEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Walter Reed National Military Medical Center · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USGeorgetown University · USNational Institutes of Health · US

Funding

Regulation Of Childhood GrowthZIAHD000640 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BARON, JEFFREY · 2009 to 2025
$24.4M
REGULATION OF SKELETAL GROWTHZ01HD000640 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BARON, JEFFREY · 1996 to 2008
$4.7M
Intramural NIH HHS Z01 HD000640
6 · The paper itself

Abstract

BACKGROUND/

objectiveMidkine (MDK) and pleiotrophin (PTN) are two closely related heparin-binding growth factors which are overexpressed in a wide variety of human cancers. We hypothesized that the concentrations of these factors in washout of biopsy needles would be higher in breast and lung cancer than in benign lesions.

methodsSeventy subjects underwent pre-operative core needle biopsies of 78 breast masses (16 malignancies). In 11 subjects, fine needle aspiration was performed ex vivo on 7 non-small cell lung cancers and 11 normal lung specimens within surgically excised lung tissue. The biopsy needle was washed with buffer for immunoassay.

resultsThe MDK/DNA and the PTN/DNA ratio in most of the malignant breast masses were similar to the ratios in benign masses except one lobular carcinoma in situ (24-fold higher PTN/DNA ratio than the average benign mass). The MDK/DNA and PTN/DNA ratio were similar in most malignant and normal lung tissue except one squamous cell carcinoma (38-fold higher MDK/DNA ratio than the average of normal lung tissue).

conclusionsBoth MDK and PTN are readily measurable in washout of needle biopsy samples from breast and lung masses and levels are highly elevated only in a specific subset of these malignancies.

Indexed as

Biopsy, Fine-NeedleBreast NeoplasmsCarrier ProteinsCytokinesFemaleHumansIntercellular Signaling Peptides and ProteinsLung NeoplasmsMaleMiddle AgedMidkineCarrier ProteinsCytokinesIntercellular Signaling Peptides and ProteinsMidkinepleiotrophinbreast masslung massMidkineneedle biopsypleiotrophin

Identifiers

PMID28946562
PMCPMC6296221
OpenAlexW2754200738

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.