ArticleNeurobiology of aging2017
Dynamic range in BOLD modulation: lifespan aging trajectories and association with performance.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Brain Structure-Function Association as a Compensatory Factor in Cognitive Aging.bioRxiv : the preprint server for biology · 2026Article
- Article
- Age-related differences in brain activity despite matched cognitive performance: A moderated-mediation analysis.Brain imaging and behavior · 2026Article
- Midlife modulation of task switching brain activity reveals age specific neural adaptation.Scientific reports · 2026Article
- Review
- Network and state specificity in connectivity-based predictions of individual behavior.Human brain mapping · 2024Article
- Network and State Specificity in Connectivity-Based Predictions of Individual Behavior.bioRxiv : the preprint server for biology · 2023Article
- Widespread fMRI BOLD Signal Overactivations during Cognitive Control in Older Adults Are Not Matched by Corresponding Increases in fPET Glucose Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural similarity across task load relates to cognitive reserve and brain maintenance measures on the Letter Sternberg task: a longitudinal study.Brain imaging and behavior · 2023Article
- Connectome-based predictive models using resting-state fMRI for studying brain aging.Experimental brain research · 2022Article
- Prediction in the Aging Brain: Merging Cognitive, Neurological, and Evolutionary Perspectives.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations.Neurobiology of aging · 2021Article
- Impact of age and cyclooxygenase inhibition on the hemodynamic response to acute cognitive challenges.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Functional Connectivity Within and BetweenBrain connectivity · 2021Article
- What Can Neural Activity Tell Us About Cognitive Resources in Aging?Frontiers in psychology · 2021Review
- Greater BOLD Variability is Associated With Poorer Cognitive Function in an Adult Lifespan Sample.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Influence of sample size and analytic approach on stability and interpretation of brain-behavior correlations in task-related fMRI data.Human brain mapping · 2021Article
- Frontostriatal white matter connectivity: age differences and associations with cognition and BOLD modulation.Neurobiology of aging · 2020Article
- Neural correlates of working memory training: Evidence for plasticity in older adults.NeuroImage · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Alteration of dynamic range of modulation to cognitive difficulty has been proposed as a salient predictor of cognitive aging. Here, we examine in 171 adults (aged 20-94 years) the effects of age on dynamic modulation of blood oxygenation-level dependent activation to difficulty in parametrically increasing working memory (WM) load (0-, 2-, 3-, and 4-back conditions). First, we examined parametric increases and decreases in activation to increasing WM load (positive modulation effect and negative modulation effect). Second, we examined the effect of age on modulation to difficulty (WM load) to identify regions that differed with age as difficulty increased (age-related positive and negative modulation effects). Weakened modulation to difficulty with age was found in both the positive modulation (middle frontal, superior/inferior parietal) and negative modulation effect (deactivated) regions (insula, cingulate, medial superior frontal, fusiform, and parahippocampal gyri, hippocampus, and lateral occipital cortex). Age-related alterations to positive modulation emerged later in the lifespan than negative modulation. Furthermore, these effects were significantly coupled in that greater upmodulation was associated with lesser downmodulation. Importantly, greater fronto-parietal upmodulation to difficulty and greater downmodulation of deactivated regions were associated with better task accuracy and upmodulation with better WM span measured outside the scanner. These findings suggest that greater dynamic range of modulation of activation to cognitive challenge is in service of current task performance, as well as generalizing to cognitive ability beyond the scanner task, lending support to its utility as a marker of successful cognitive aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.