ReviewCurrent opinion in biotechnology2018
Engineering modular polyketide synthases for production of biofuels and industrial chemicals.
Review in Current opinion in biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto-Acyl Carrier Proteins.Chembiochem : a European journal of chemical biology · 2026Article
- A Simple and Versatile Cell-Free Expression Method for Producing Secondary Metabolites.ACS synthetic biology · 2026Article
- Functional and genomic profiling of lactic acid bacteria reveals specific traits as potential probiotics.Frontiers in microbiology · 2026Article
- NRPS and PKS pathways in actinomycetes: A review of biosynthetic diversity and bioactive potential.Current research in pharmacology and drug discovery · 2026Review
- Improving polyketide biosynthesis by rescuing the translation of truncated mRNAs into functional polyketide synthase subunits.Nature communications · 2025Article
- Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra.Nature microbiology · 2023Article
- Structure of a modular polyketide synthase reducing region.Structure (London, England : 1993) · 2023Article
- Engineering DszC Mutants from Transition State Macrodipole Considerations and Evolutionary Sequence Analysis.Journal of chemical information and modeling · 2023Article
- ClusterCAD 2.0: an updated computational platform for chimeric type I polyketide synthase and nonribosomal peptide synthetase design.Nucleic acids research · 2023Article
- Microbial pathways for advanced biofuel production.Biochemical Society transactions · 2022Review
- Reverse β-oxidation pathways for efficient chemical production.Journal of industrial microbiology & biotechnology · 2022Article
- Recent advances in metabolic engineering of microorganisms for advancing lignocellulose-derived biofuels.Bioengineered · 2022Review
- Heterologous Expression, Purification, and Characterization of Type II Polyketide Synthase Acyl Carrier Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Microbial production of advanced biofuels.Nature reviews. Microbiology · 2021Review
- Review
- Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli.ACS synthetic biology · 2019Article
- Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery.Marine drugs · 2019Review
- Emerging evolutionary paradigms in antibiotic discovery.Journal of industrial microbiology & biotechnology · 2019Review
- Modular type I polyketide synthase acyl carrier protein domains share a common N-terminally extended fold.Scientific reports · 2019Article
- Dalmanol biosyntheses require coupling of two separate polyketide gene clusters.Chemical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Polyketide synthases (PKSs) are one of the most profound biosynthetic factories for producing polyketides with diverse structures and biological activities. These enzymes have been historically studied and engineered to make un-natural polyketides for drug discovery, and have also recently been explored for synthesizing biofuels and industrial chemicals due to their versatility and customizability. Here, we review recent advances in the mechanistic understanding and engineering of modular PKSs for producing polyketide-derived chemicals, and provide perspectives on this relatively new application of PKSs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.