ArticleBritish journal of pharmacology2017
Human podocytes express functional thermosensitive TRPV channels.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Piezo1-Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress.Acta physiologica (Oxford, England) · 2026Review
- Non-voltage-gated CaAmerican journal of physiology. Renal physiology · 2024Review
- Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease.International journal of molecular sciences · 2024Review
- N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release.International journal of molecular sciences · 2023Article
- Transient Receptor Potential Vanilloid in the Brain Gliovascular Unit: Prospective Targets in Therapy.Pharmaceutics · 2021Review
- Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts.Cell death & disease · 2020Article
- Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood-Brain Barrier Reveals Interspecies Differences.Frontiers in cell and developmental biology · 2020Article
- Charting a TRP to Novel Therapeutic Destinations for Kidney Diseases.Trends in pharmacological sciences · 2019Review
- Effects of Chronic Administration of Capsaicin on Biomarkers of Kidney Injury in Male Wistar Rats with Experimental Diabetes.Molecules (Basel, Switzerland) · 2018Article
- Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis.Scientific reports · 2018Article
- Human podocytes express functional thermosensitive TRPV channels.British journal of pharmacology · 2017Article
- NovelIndian journal of nephrologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHeat-sensitive transient receptor potential vanilloid (TRPV) channels are expressed in various epithelial tissues regulating, among else, barrier functions. Their expression is well established in the distal nephron; however, we have no data about their presence in podocytes. As podocytes are indispensable in the formation of the glomerular filtration barrier, we investigated the presence and function of Ca EXPERIMENTAL APPROACH: Expression of TRPV1-4 channels was investigated at protein (immunocytochemistry, Western blot) and mRNA (Q-PCR) level in a conditionally immortalized human podocyte cell line. Channel function was assessed by measuring intracellular Ca KEY
resultsThermosensitive TRP channels were expressed in podocytes. The TRPV1-specific agonists capsaicin and resiniferatoxin did not affect the intracellular Ca CONCLUSION AND IMPLICATIONS: Our results indicate the functional presence of TRPV4 and other thermosensitive TRPV channels in human podocytes and raise the possibility of their involvement in the regulation of glomerular filtration barrier.
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