ArticlePloS one2017
The promoter region of lapA and its transcriptional regulation by Fis in Pseudomonas putida.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Mycorrhiza helper bacteria as stage-specific modulators of fungal development.Frontiers in plant science · 2026Review
- Directing microbial co-culture composition using cybernetic control.Cell reports methods · 2025Article
- Catabolism and interactions of syntrophic propionate- and acetate oxidizing microorganisms under mesophilic, high-ammonia conditions.Frontiers in microbiology · 2024Article
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- Tryptone in Growth Media EnhancesMicroorganisms · 2022Article
- From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.Annual review of microbiology · 2020Review
- MapA, a Second Large RTX Adhesin Conserved across the Pseudomonads, Contributes to Biofilm Formation by Pseudomonas fluorescens.Journal of bacteriology · 2020Article
- Defining the Genetic Basis of Plant⁻Endophytic Bacteria Interactions.International journal of molecular sciences · 2019Review
- Transcriptional organization, regulation and functional analysis of flhF and fleN in Pseudomonas putida.PloS one · 2019Article
- Correction: The promoter region of lapA and its transcriptional regulation by Fis in Pseudomonas putida.PloS one · 2018Article
- Colonization efficiency of Pseudomonas putida is influenced by Fis-controlled transcription of nuoA-N operon.PloS one · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LapA is the biggest protein in Pseudomonas putida and a key factor for biofilm formation. Its importance and posttranslational regulation is rather thoroughly studied but less is known about the transcriptional regulation. Here we give evidence that transcription of lapA in LB-grown bacteria is initiated from six promoters, three of which display moderate RpoS-dependence. The global transcription regulator Fis binds to the lapA promoter area at six positions in vitro, and Fis activates the transcription of lapA while overexpressed in cells. Two of the six Fis binding sites, Fis-A7 and Fis-A5, are necessary for the positive effect of Fis on the transcription of lapA in vivo. Our results indicate that Fis binding to the Fis-A7 site increases the level of transcription from the most distal promoter of lapA, whereas Fis binding to the Fis-A5 site could be important for modifying the promoter area topology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.