Observational studyPloS one2017
Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study.
Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Multiple relapses of cryptogenic organizing pneumonia: A case report.Experimental and therapeutic medicine · 2026Article
- Rethinking treatment approaches to organising pneumonia: more lessons to be learned from COVID-19.ERJ open research · 2026Article
- Korean Guidelines for Diagnosis and Management of Interstitial Lung Disease: Cryptogenic Organizing Pneumonia.Tuberculosis and respiratory diseases · 2025Article
- How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients.Blood · 2024Review
- Delayed organising pneumonia in an immunocompromised host after a mild COVID-19 infection.BMJ case reports · 2023Article
- Case report: Coexistence of triple-seronegative myasthenia gravis and pathology-proven cryptogenic organizing pneumonia.Frontiers in neurology · 2023Article
- Update on cryptogenic organizing pneumonia.Frontiers in medicine · 2023Review
- The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Rituximab for steroid-resistant organising pneumonia in a woman with rheumatoid arthritis.BMJ case reports · 2022Article
- Clarithromycin in Post COVID-19 Organizing pneumonia.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2022Article
- Two cases of cryptogenic organizing pneumonia masquerading as tuberculosis (TB) in a TB endemic area.Respirology case reports · 2022Article
- Cryptogenic organising pneumonia: current understanding of an enigmatic lung disease.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Case of Severe Treatment-Resistant Cryptogenic Organizing Pneumonia.Acta medica Lituanic · 2021Article
- COVID-19 Infection: Implications for Perioperative and Critical Care Physicians.Anesthesiology · 2020Review
- Acute fibrinous organising pneumonia presenting as a cavitary lung lesion and treatment response to azithromycin.BMJ case reports · 2019Article
- Surgical management of organizing pneumonia: a retrospective study of 24 cases in a single Centre.Journal of cardiothoracic surgery · 2019Article
- Spontaneous resolution of thoracic radiation therapy-induced organizing pneumonia: A case series.Respiratory medicine case reports · 2019Article
- Current Approach to Non-Infectious Pulmonary Complications of Hematopoietic Stem Cell Transplantation.Balkan medical journal · 2018Review
- Application of Innovative 3D Pathological Tactic for Diagnosis of Organizing Pneumonia.In vivo (Athens, Greece)Article
- Corticosteroid treatment for persistent pulmonary infiltrates following COVID-19 infection: Clearing the fog?Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCryptogenic organizing pneumonia (COP) is a clinicopathological syndrome of unknown origin. Corticosteroids are the standard treatment, but clarithromycin (CAM) is also effective. The aim of this observational retrospective study was to compare the results of CAM versus prednisone (PRE) treatment in patients with biopsy-proven OP without respiratory insufficiency. MATERIAL AND
methodsIn a 15-year period, 40 patients were treated with CAM (500 mg twice daily orally for 3 months) and 22 with PRE (mean initial dose of 0.67 ± 0.24 mg/kg/d for a mean of 8.59 ± 3.05 months).
resultsThe clinical presentation, laboratory, and radiological findings did not differ markedly between patients treated with CAM and PRE, with the exception of a higher frequency of sweats (55% vs. 23%; p < 0.015), ground glass opacities (95% vs. 50%; p <0.0001) and nodular lesions (45% vs. 18%; p = 0.036) in the CAM group. A complete response was achieved in 35(88%) patients treated with CAM and in all treated with PRE. Patients treated with PRE relapsed more frequently than those treated with CAM (54.5% vs. 10%; p < 0.0001). Corticosteroid-related adverse events were noticed in 8(6.5%) patients (with one death), but CAM caused only one (2.5%) allergic reaction. A FVC >80% identified patients who might be successfully treated with CAM with a sensitivity of 60% and a specificity of 88.57% (AUC 0.869; 95% CI 0.684-1; p = 0.008); the figures for the FEV1 were >70%, a sensitivity of 60%, and a specificity of 91.43% (AUC 0.809; 95%CI 0.609-1; p = 0.027).
conclusionsCAM can be used to treat COP patients in whom the pulmonary function parameters are within normal limits. Such therapy is shorter, better tolerated, and associated with fewer adverse events and relapses than is PRE. However, the therapy is ineffective in some patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.